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Filtering by: Subject Tolbutamide -- Physiological effect Creator Eshleman, Amy J. Degree Field Toxicology

Pyrethroid insecticide interaction with the GABAA receptor and the peripheral-type benzodiazepine receptor of rainbow trout brain

Creator:

Eshleman, Amy J.

Abstract:

The peripheral-type benzodiazepine receptor (PTBR) of trout brain was pharmacologically characterized and pyrethroid interaction with this site investigated. High-affinity binding sites for [³H]PK 11195 were detected in brain membranes of rainbow trout; these shared some of the characteristics of the PTBR of rodent brain (i.e., high affinity for PK 11195...

Resource Type:

Dissertation

Full Text:

effect a GABA- dependent inhibition of [35S]TBPS binding. Ro5-4864, which showed micromolar affinity