Microbial communities are responsible for the bulk of biogeochemical processing in temporary headwater streams, yet there is still relatively little known about how community structure and function respond to periodic drying. Moreover, the ability to sample temporary habitats can be a logistical challenge due to the limited capability to measure...
Microbial communities are responsible for the bulk of biogeochemical processing in temporary headwater streams, yet there is still relatively little known about how community structure and function respond to periodic drying. Moreover, the ability to sample temporary habitats can be a logistical challenge due to the limited capability to measure...
Microbial communities are responsible for the bulk of biogeochemical processing in temporary headwater streams, yet there is still relatively little known about how community structure and function respond to periodic drying. Moreover, the ability to sample temporary habitats can be a logistical challenge due to the limited capability to measure...
Exotic species dominate many communities; however the functional significance of species’ biogeographic origin remains highly contentious. This debate is fuelled in part by the lack of globally replicated, systematic data assessing the relationship between species provenance, function and response to perturbations. We examined the abundance of native and exotic plant...
Exotic species dominate many communities; however the functional significance of species’ biogeographic origin remains highly contentious. This debate is fuelled in part by the lack of globally replicated, systematic data assessing the relationship between species provenance, function and response to perturbations. We examined the abundance of native and exotic plant...
Fidelity to migratory destinations is an important driver of connectivity in marine and avian species. Here we assess the role of maternally directed learning of migratory habitats, or migratory culture, on the population structure of the endangered Australian and New Zealand southern right whale. Using DNA profiles, comprising mitochondrial DNA...
Fidelity to migratory destinations is an important driver of connectivity in marine and avian species. Here we assess the role of maternally directed learning of migratory habitats, or migratory culture, on the population structure of the endangered Australian and New Zealand southern right whale. Using DNA profiles, comprising mitochondrial DNA...
The Leguminosae has emerged as a model for studying angiosperm plastome evolution because of its striking diversity of structural rearrangements and sequence variation. However, most of what is known about legume plastomes comes from few genera representing a subset of lineages in subfamily Papilionoideae. We investigate plastome evolution in subfamily...
The Leguminosae has emerged as a model for studying angiosperm plastome evolution because of its striking diversity of structural rearrangements and sequence variation. However, most of what is known about legume plastomes comes from few genera representing a subset of lineages in subfamily Papilionoideae. We investigate plastome evolution in subfamily...
Using published dairy cattle liver transcriptomics dataset along with novel blood biomarkers of liver function, metabolism,
and inflammation we have attempted an integrative systems biology approach applying the classical functional enrichment
analysis using DAVID, a newly-developed Dynamic Impact Approach (DIA), and an upstream gene network analysis using
Ingenuity Pathway Analysis...
Using published dairy cattle liver transcriptomics dataset along with novel blood biomarkers of liver function, metabolism,
and inflammation we have attempted an integrative systems biology approach applying the classical functional enrichment
analysis using DAVID, a newly-developed Dynamic Impact Approach (DIA), and an upstream gene network analysis using
Ingenuity Pathway Analysis...
Organic agriculture requires cultivars that can adapt to organic crop management systems without the use of synthetic
pesticides as well as genotypes with improved nutritional value. The aim of this study encompassing 16 experiments was to
compare 23 broccoli cultivars for the content of phytochemicals associated with health promotion grown...
Organic agriculture requires cultivars that can adapt to organic crop management systems without the use of synthetic
pesticides as well as genotypes with improved nutritional value. The aim of this study encompassing 16 experiments was to
compare 23 broccoli cultivars for the content of phytochemicals associated with health promotion grown...
The filamentous fungus Neurospora crassa responds to light in complex ways. To thoroughly
study the transcriptional response of this organism to light, RNA-seq was used to analyze capped and
polyadenylated mRNA prepared from mycelium grown for 24 hr in the dark and then exposed to light for
0 (control) 15,...
The filamentous fungus Neurospora crassa responds to light in complex ways. To thoroughly
study the transcriptional response of this organism to light, RNA-seq was used to analyze capped and
polyadenylated mRNA prepared from mycelium grown for 24 hr in the dark and then exposed to light for
0 (control) 15,...
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Background: Like other transformative healthcare initiatives, patient-centered medical home (PCMH) implementation requires substantial investments of time and resources. Even though PCMH and PCMH-like models are being implemented by multiple provider practices and health systems, little is known about what facilitates their implementation. The purpose of this study was to assess...
Background: Like other transformative healthcare initiatives, patient-centered medical home (PCMH) implementation requires substantial investments of time and resources. Even though PCMH and PCMH-like models are being implemented by multiple provider practices and health systems, little is known about what facilitates their implementation. The purpose of this study was to assess...
Background: Like other transformative healthcare initiatives, patient-centered medical home (PCMH) implementation requires substantial investments of time and resources. Even though PCMH and PCMH-like models are being implemented by multiple provider practices and health systems, little is known about what facilitates their implementation. The purpose of this study was to assess...
Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs. In the absence...
Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs. In the absence...
Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However, the identity of the ligand(s) responsible for such AHR-mediated activation within the gut remains to be firmly established....
Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However, the identity of the ligand(s) responsible for such AHR-mediated activation within the gut remains to be firmly established....
The ongoing retreat of glaciers globally is one of the clearest manifestations of recent global warming associated with rising greenhouse gas concentrations. By comparison, the importance of greenhouse gases in driving glacier retreat during the most recent deglaciation, the last major interval of global warming, is unclear due to uncertainties...
The ongoing retreat of glaciers globally is one of the clearest manifestations of recent global warming associated with rising greenhouse gas concentrations. By comparison, the importance of greenhouse gases in driving glacier retreat during the most recent deglaciation, the last major interval of global warming, is unclear due to uncertainties...
The ongoing retreat of glaciers globally is one of the clearest manifestations of recent global warming associated with rising greenhouse gas concentrations. By comparison, the importance of greenhouse gases in driving glacier retreat during the most recent deglaciation, the last major interval of global warming, is unclear due to uncertainties...
The 1994 Northwest Forest Plan (NWFP) shifted federal lands management from a focus on timber production to ecosystem management and biodiversity conservation. The plan established a network of conservation reserves and an ecosystem management strategy on ~10 million hectares from northern California to Washington State, USA, within the range of...
The 1994 Northwest Forest Plan (NWFP) shifted federal lands management from a focus on timber production to ecosystem management and biodiversity conservation. The plan established a network of conservation reserves and an ecosystem management strategy on ~10 million hectares from northern California to Washington State, USA, within the range of...
Iron (Fe) and copper (Cu) are essential cofactors for microbial metalloenzymes, but little is known about the metalloenyzme inventory of anaerobic marine microbial communities despite their importance to the nitrogen cycle. We compared dissolved O₂ , NO₃⁻, NO₂⁻, Fe and Cu concentrations with nucleic acid sequences encoding Fe and Cu-binding...
Iron (Fe) and copper (Cu) are essential cofactors for microbial metalloenzymes, but little is known about the metalloenyzme inventory of anaerobic marine microbial communities despite their importance to the nitrogen cycle. We compared dissolved O₂ , NO₃⁻, NO₂⁻, Fe and Cu concentrations with nucleic acid sequences encoding Fe and Cu-binding...
Iron (Fe) and copper (Cu) are essential cofactors for microbial metalloenzymes, but little is known about the metalloenyzme inventory of anaerobic marine microbial communities despite their importance to the nitrogen cycle. We compared dissolved O₂ , NO₃⁻, NO₂⁻, Fe and Cu concentrations with nucleic acid sequences encoding Fe and Cu-binding...
The peptidyl nucleoside blasticidin S (BS) isolated from Streptomyces griseochromogenes was the first non-mercurial fungicide used on a large scale to prevent rice blast. In the biosynthesis of BS, leucylblasticidin S (LBS) was suggested as the penultimate metabolite with 20-fold less inhibitory activity than the final product BS. Incomplete conversion...
The peptidyl nucleoside blasticidin S (BS) isolated from Streptomyces griseochromogenes was the first non-mercurial fungicide used on a large scale to prevent rice blast. In the biosynthesis of BS, leucylblasticidin S (LBS) was suggested as the penultimate metabolite with 20-fold less inhibitory activity than the final product BS. Incomplete conversion...
Repetitive sequences present a challenge for genome sequence assembly, and highly similar segmental duplications may
disappear from assembled genome sequences. Having found a surprising lack of observable phenotypic deviations and
non-Mendelian segregation in Arabidopsis thaliana mutants in SEC10, a gene encoding a core subunit of the exocyst
tethering complex, we...
Repetitive sequences present a challenge for genome sequence assembly, and highly similar segmental duplications may
disappear from assembled genome sequences. Having found a surprising lack of observable phenotypic deviations and
non-Mendelian segregation in Arabidopsis thaliana mutants in SEC10, a gene encoding a core subunit of the exocyst
tethering complex, we...
Eucalypts are the world’s most widely planted hardwood trees. Their outstanding diversity, adaptability and growth have
made them a global renewable resource of fibre and energy. We sequenced and assembled >94% of the 640-megabase
genome of Eucalyptus grandis. Of 36,376 predicted protein-coding genes, 34% occur in tandem duplications, the largest...
Eucalypts are the world’s most widely planted hardwood trees. Their outstanding diversity, adaptability and growth have
made them a global renewable resource of fibre and energy. We sequenced and assembled >94% of the 640-megabase
genome of Eucalyptus grandis. Of 36,376 predicted protein-coding genes, 34% occur in tandem duplications, the largest...
Fungal hyphae are among the most highly polarized cells. Hyphal polarized
growth is supported by tip-directed transport of secretory vesicles, which accumulate temporarily
in a stratified manner in an apical vesicle cluster, the Spitzenkörper. The exocyst complex
is required for tethering of secretory vesicles to the apical plasma membrane. We...
Fungal hyphae are among the most highly polarized cells. Hyphal polarized
growth is supported by tip-directed transport of secretory vesicles, which accumulate temporarily
in a stratified manner in an apical vesicle cluster, the Spitzenkörper. The exocyst complex
is required for tethering of secretory vesicles to the apical plasma membrane. We...
The goal of this project was to investigate the effects and possible developmental disease implication of chronic dietary
TCDD exposure on global gene expression anchored to histopathologic analysis in juvenile zebrafish by functional genomic,
histopathologic and analytic chemistry methods. Specifically, juvenile zebrafish were fed Biodiet starter with TCDD added at...
The goal of this project was to investigate the effects and possible developmental disease implication of chronic dietary
TCDD exposure on global gene expression anchored to histopathologic analysis in juvenile zebrafish by functional genomic,
histopathologic and analytic chemistry methods. Specifically, juvenile zebrafish were fed Biodiet starter with TCDD added at...
Circadian clocks coordinate physiological, neurological, and behavioral functions into circa 24 hour rhythms, and the
molecular mechanisms underlying circadian clock oscillations are conserved from Drosophila to humans. Clock oscillations
and clock-controlled rhythms are known to dampen during aging; additionally, genetic or environmental clock disruption
leads to accelerated aging and increased...
Circadian clocks coordinate physiological, neurological, and behavioral functions into circa 24 hour rhythms, and the
molecular mechanisms underlying circadian clock oscillations are conserved from Drosophila to humans. Clock oscillations
and clock-controlled rhythms are known to dampen during aging; additionally, genetic or environmental clock disruption
leads to accelerated aging and increased...
Resazurin (Raz) and its reaction product resorufin
(Rru) have increasingly been used as reactive tracers to quantify
metabolic activity and hyporheic exchange in streams.
Previous work has indicated that these compounds undergo
sorption in stream sediments. We present laboratory experiments
on Raz and Rru transport, sorption, and transformation,
consisting of...
Resazurin (Raz) and its reaction product resorufin
(Rru) have increasingly been used as reactive tracers to quantify
metabolic activity and hyporheic exchange in streams.
Previous work has indicated that these compounds undergo
sorption in stream sediments. We present laboratory experiments
on Raz and Rru transport, sorption, and transformation,
consisting of...
Resazurin (Raz) and its reaction product resorufin
(Rru) have increasingly been used as reactive tracers to quantify
metabolic activity and hyporheic exchange in streams.
Previous work has indicated that these compounds undergo
sorption in stream sediments. We present laboratory experiments
on Raz and Rru transport, sorption, and transformation,
consisting of...
Advances in forest carbon mapping have the potential
to greatly reduce uncertainties in the global carbon
budget and to facilitate effective emissions mitigation strategies
such as REDDC (Reducing Emissions from Deforestation
and Forest Degradation). Though broad-scale mapping
is based primarily on remote sensing data, the accuracy of
resulting forest carbon...
Advances in forest carbon mapping have the potential
to greatly reduce uncertainties in the global carbon
budget and to facilitate effective emissions mitigation strategies
such as REDDC (Reducing Emissions from Deforestation
and Forest Degradation). Though broad-scale mapping
is based primarily on remote sensing data, the accuracy of
resulting forest carbon...
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species’ threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that...