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  • SpitsbergenJanMicrobiologyHistopathologicAlterationsAssociated.pdf

    Creator:
    Liu, Qing, Spitsbergen, Jan M., Cariou, Ronan, and et al.
    Abstract:
    The goal of this project was to investigate the effects and possible developmental disease implication of chronic dietary TCDD exposure on global gene expression anchored to histopathologic analysis in juvenile zebrafish by functional genomic, histopathologic and analytic chemistry methods. Specifically, juvenile zebrafish were fed Biodiet starter with TCDD added at...
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    Global Gene Expression Due to Chronic Dietary TCDD Exposure in Juvenile Zebrafish. PLoS ONE 9(7

  • BissonWilliamEnvironMoleToxIntestineSelectiveFarnesoid.pdf

    Creator:
    Jiang, Changtao, Xie, Cen, Lv, Ying, Bisson, William H., and et al.
    Abstract:
    The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
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    iv e ex pr es si on FX R Sh p Fg f1 9 ** ** a 0.04 0.03 0.02 0.01 0.00 15 20 25 30 35

  • ConnollyLanelleBiochemistryBiophysicsEpigeneticControlEffector.pdf

    Creator:
    Soyer, Jessica L., El Ghalid, Mennat, Glaser, Nicolas, Connolly, Lanelle R., Freitag, Michael, and et al.
    Abstract:
    Plant pathogens secrete an arsenal of small secreted proteins (SSPs) acting as effectors that modulate host immunity to facilitate infection. SSP-encoding genes are often located in particular genomic environments and show waves of concerted expression at diverse stages of plant infection. To date, little is known about the regulation of...
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    ) and comprise 36% of the genome but only 5% of the genes [7]. One hundred and twenty-two (,20%) of

  • HeppellScottFisheriesWildlifePopulationStructurePhylogeography.pdf

    Creator:
    Jackson, Alexis M., Semmens, Brice X., de Mitcheson, Yvonne Sadovy, Heppell, Scott A., and et al.
    Abstract:
    To address patterns of genetic connectivity in a mass-aggregating marine fish, we analyzed genetic variation in mitochondrial DNA (mtDNA), microsatellites, and single nucleotide polymorphisms (SNPs) for Nassau grouper (Epinephelus striatus). We expected Nassau grouper to exhibit genetic differentiation among its subpopulations due to its reproductive behavior and retentive oceanographic conditions...
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    of the Environment, Grand Cayman, British West Indies, 7 Departmento de Biologı́a Marina

  • TiwariVijayCropSoilSciDevelopmentDGenome.pdf

    Creator:
    Wang, Yi, Drader, Thomas, Tiwari, Vijay K., Leonard, Jeff, and et al.
    Abstract:
    Background: Mapping and map-based cloning of genes that control agriculturally and economically important traits remain great challenges for plants with complex highly repetitive genomes such as those within the grass tribe, Triticeae. Mapping limitations in the Triticeae are primarily due to low frequencies of polymorphic gene markers and poor genetic...
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    poor regions [7]. Taken together, gene- based markers might not be able to produce a complete framework

  • NyarkoAfuaBiochemBiophyNetworkAssemblyFactors.pdf

    Creator:
    Baßler, Jochen, Paternoga, Helge, Holdermann, Iris, Nyarko, Afua, Clark, Sarah A., Barbar, Elisar, and et al.
    Abstract:
    Eukaryotic ribosome biogenesis involves ~200 assembly factors, but how these contribute to ribosome maturation is poorly understood. Here, we identify a network of factors on the nascent 60S subunit that actively remodels preribosome structure. At its hub is Rsa4, a direct substrate of the force-generating ATPase Rea1. We show that...
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    vitro binding assay of MBP-Nsa2 with Rsa4. Purified MBP-Nsa2 (lane 4–6), MBP-Nsa2 84–96 aa (lane 7–9

  • BionazMassimoAnimalRangelandSciIntegrativeAnalysesHepatic.pdf

    Creator:
    Shahzad, Khuram, Bionaz, Massimo, Trevisi, Erminio, and et al.
    Abstract:
    Using published dairy cattle liver transcriptomics dataset along with novel blood biomarkers of liver function, metabolism, and inflammation we have attempted an integrative systems biology approach applying the classical functional enrichment analysis using DAVID, a newly-developed Dynamic Impact Approach (DIA), and an upstream gene network analysis using Ingenuity Pathway Analysis...
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    expression was ,7% of total DEG. Most of the differences in gene expression between OF vs. RE occurred during