Index Catalog // ScholarsArchive@OSU

Creator:: Hubbard, Troy D., Murray, Iain A, Bisson, William H., and et al.
Abstract:: Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However, the identity of the ligand(s) responsible for such AHR-mediated activation within the gut remains to be firmly established....
Full Text:: microbiota-derived indoles’ Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne

Creator:: Hubbard, Troy D., Murray, Iain A, Bisson, William H., and et al.
Abstract:: Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However, the identity of the ligand(s) responsible for such AHR-mediated activation within the gut remains to be firmly established....
Full Text:: receptor to sense microbiota-derived indoles Troy D. Hubbard1,2, Iain A. Murray2, William H. Bisson3

Creator:: Buck, Julia C., Hua, Jessica, Brogan, William R. III, Dang, Trang D., Urbina, Jenny, Blaustein, Andrew R., and et al.
Abstract:: Anthropogenic and natural stressors often interact to affect organisms. Amphibian populations are undergoing unprecedented declines and extinctions with pesticides and emerging infectious diseases implicated as causal factors. Although these factors often co-occur, their effects on amphibians are usually examined in isolation. We hypothesized that exposure of larval and metamorphic amphibians...
Full Text:: Julia C. Buck1,2*, Jessica Hua3¤a, William R. Brogan, III3¤b, Trang D. Dang2, Jenny Urbina4, Randall J

Creator:: Buck, Julia C., Hua, Jessica, Brogan, William R. III, Dang, Trang D., Urbina, Jenny, Blaustein, Andrew R., and et al.
Abstract:: Anthropogenic and natural stressors often interact to affect organisms. Amphibian populations are undergoing unprecedented declines and extinctions with pesticides and emerging infectious diseases implicated as causal factors. Although these factors often co-occur, their effects on amphibians are usually examined in isolation. We hypothesized that exposure of larval and metamorphic amphibians...
Full Text:: ). Plates were incubated at 22°C for 7-11 d prior to 41 use. On a weekly basis, 10-24 plates were flooded

Creator:: Kang, Y., Nian, H., Rajendran, P., Löhr, C. V., Bisson, W. H., Williams, D. E., and et al.
Abstract:: Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Full Text:: using Students t-test. (d) G2/M cell cycle arrest at 48 h required the presence of p21. (e) In the

Creator:: Kang, Y., Nian, H., Rajendran, P., Löhr, C. V., Bisson, W. H., Williams, D. E., and et al.
Abstract:: Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...

Creator:: Jiang, Changtao, Xie, Cen, Lv, Ying, Bisson, William H., and et al.
Abstract:: The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:: Figure 1. Ligand docking of FXR agonist and antagonist. Docking of agonist CDCA (a, b, d, e, f

Creator:: Jiang, Changtao, Xie, Cen, Lv, Ying, Bisson, William H., and et al.
Abstract:: The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:: . Amin4, William H. Bisson5, Yulan Liu3, Oksana Gavrilova6, Andrew D. Patterson7 & Frank J. Gonzalez1

Creator:: Baßler, Jochen, Paternoga, Helge, Holdermann, Iris, Nyarko, Afua, Clark, Sarah A., Barbar, Elisar, and et al.
Abstract:: Eukaryotic ribosome biogenesis involves ~200 assembly factors, but how these contribute to ribosome maturation is poorly understood. Here, we identify a network of factors on the nascent 60S subunit that actively remodels preribosome structure. At its hub is Rsa4, a direct substrate of the force-generating ATPase Rea1. We show that...
Full Text:: Sinning,1 and Ed Hurt1 1Biochemistry Center of Heidelberg University, INF328, D-69120 Heidelberg, Germany

Creator:: Ni, Junjian, Pujar, Anuradha, Youens-Clark, Ken, Jaiswal, Pankaj, and et al.
Abstract:: Gramene is a comparative information resource for plants that integrates data across diverse data domains. In this article, we describe the development of a quantitative trait loci (QTL) database and illustrate how it can be used to facilitate both the forward and reverse genetics research. The QTL database contains the...
Full Text:: , Immanuel Yap1, Pankaj Jaiswal1,�, Isaak Tecle1, Chih-Wei Tung1, Liya Ren2, William Spooner2, Xuehong Wei2

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