Honey bee colony losses are a major concern in the USA and across the globe. Long-term data on losses
are critical for putting yearly losses in context. US colony loss surveys have been conducted yearly since the winter
of 2006–2007. Here, we report the results from the eighth annual survey...
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included below each
question. A required response is indicated by a “*.” Definitions for a “colony
We investigated DNA methylomes of pediatric B-cell
acute lymphoblastic leukemias (B-ALLs) using
whole-genome bisulfite sequencing and high-definition
microarrays, along with RNA expression
profiles. Epigenetic alteration of B-ALLs occurred in
two tracks: de novo methylation of small functional
compartments and demethylation of large intercompartmental
backbones. The deviations were exaggerated
in lamina-associated...
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Lee, S. T., Muench, M. O., Fomin, M. E., Xiao, J., Zhou, M., de Smith, A., ... &
Wiemels, J. L. (2015
We investigated DNA methylomes of pediatric B-cell
acute lymphoblastic leukemias (B-ALLs) using
whole-genome bisulfite sequencing and high-definition
microarrays, along with RNA expression
profiles. Epigenetic alteration of B-ALLs occurred in
two tracks: de novo methylation of small functional
compartments and demethylation of large intercompartmental
backbones. The deviations were exaggerated
in lamina-associated...
Honey bee colony losses are a major concern in the USA and across the globe. Long-term data on losses
are critical for putting yearly losses in context. US colony loss surveys have been conducted yearly since the winter
of 2006–2007. Here, we report the results from the eighth annual survey...
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apiary^ is a proxy ques-
tion for CCD as it is one of the classically
302 K.V. Lee et al.
described
A large amount of organic carbon is stored in high-latitude soils. A substantial proportion of this carbon stock is vulnerable and may decompose rapidly due to temperature increases that are already greater than the global average. It is therefore crucial to quantify and understand carbon exchange between the atmosphere and...
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Carbon budget estimation of a subarctic catchment using
Large amount of organic carbon is stored in high latitude soils. A substantial proportion of this carbon stock is vulnerable and may decompose rapidly due to temperature increases that are already greater than the global average. It is therefore crucial to quantify and understand carbon exchange between the atmosphere and...
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Carbon budget estimation of a subarctic catchment using
Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However, the identity of the ligand(s) responsible for such AHR-mediated activation within the gut remains to be firmly established....
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. Lee, J., Jayaraman, A. & Wood, T. K. Indole is an inter-species biofilm signal mediated by SdiA. BMC
The terrestrial biosphere sequesters up to a
third of annual anthropogenic carbon dioxide emissions,
offsetting a substantial portion of greenhouse
gas forcing of the climate system. Although a number
of factors are responsible for this terrestrial carbon
sink, atmospheric nitrogen deposition contributes by
enhancing tree productivity and promoting carbon
storage...
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., Brzostek, E., Burton, A., ... &
Wickings, K. (2014). Chronic nitrogen additions suppress decomposition and
To address patterns of genetic connectivity in a mass-aggregating marine fish, we analyzed genetic variation in
mitochondrial DNA (mtDNA), microsatellites, and single nucleotide polymorphisms (SNPs) for Nassau grouper (Epinephelus
striatus). We expected Nassau grouper to exhibit genetic differentiation among its subpopulations due to its reproductive
behavior and retentive oceanographic conditions...
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0.921 0.854
13. Lee Stocking nA 14 14 8 10 5 22 7 14 15
Ho 0.739 0.913 0.609 0.913 0.565 0.957
Eukaryotic ribosome biogenesis involves ~200 assembly
factors, but how these contribute to ribosome
maturation is poorly understood. Here, we
identify a network of factors on the nascent 60S subunit
that actively remodels preribosome structure. At its hub is
Rsa4, a direct substrate of the force-generating ATPase
Rea1. We show that...
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,1 Sander Granneman,2 Clara Barrio-Garcia,4
Afua Nyarko,5 Woonghee Lee,6,7 Gunter Stier,1 Sarah A
To address patterns of genetic connectivity in a mass-aggregating marine fish, we analyzed genetic variation in
mitochondrial DNA (mtDNA), microsatellites, and single nucleotide polymorphisms (SNPs) for Nassau grouper (Epinephelus
striatus). We expected Nassau grouper to exhibit genetic differentiation among its subpopulations due to its reproductive
behavior and retentive oceanographic conditions...
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(Epinephelus striatus), a Mass-Aggregating Marine Fish
Population Structure and Phylogeography in Nassau
Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs. In the absence...
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in
Mouse Embryonic Stem Cells
Das, P. P., Hendrix, D. A., Apostolou, E., Buchner, A. H., Canver, M
Trophic interactions within and among species vary widely across spatial scales and species’ ontogeny. However, the drivers and implications of this variability are not well understood. Juvenile Chinook salmon Oncorhynchus tshawytscha have a wide distribution, ranging from northern California to the eastern Bering Sea in North America, but it is...
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high
prey quality (Lee et al. 2006) and a fish community
composed largely of salmonids (Orsi et al
To determine how well DNA barcodes from the chloroplast region perform in forest dynamics plots
(FDPs) from global CTFS-ForestGEO network, we analyzed DNA barcoding sequences of 1277 plant
species from a wide phylogenetic range (3 FDPs in tropics, 5 in subtropics and 5 in temperate zone)
and compared the rates...
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. Evolution 24, 23–47 (1970).
48. Fenner, M., Lee, W. G. & Wilson, J. B. A comparative study of the
Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs. In the absence...
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Mouse Embryonic Stem Cells
Partha Pratim Das, David A. Hendrix, Effie Apostolou, Alice H. Buchner
Carbonate communities:The activity of anaerobic methane oxidizing microbes facilitates
precipitation of vast quantities of authigenic carbonate at methane seeps. Here we demonstrate
the significant role of carbonate rocks in promoting diversity by providing unique habitat
and food resources for macrofaunal assemblages at seeps on the Costa Rica margin
(400–1850 m)....
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Carbonate at Costa Rica Methane Seeps
Levin, L. A., Mendoza, G. F., Grupe, B. M., Gonzalez, J. P., Jellison
In the future, Earth will be warmer, precipitation events will be more extreme, global mean sea level will rise, and many arid and semiarid regions will be drier. Human modifications of landscapes will also occur at an accelerated rate as developed areas increase in size and population density. We now...
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climatic and land use changes: A review of methods and research needs
Forecasting the response of Earth's
In the future, Earth will be warmer, precipitation events will be more extreme, global mean sea level will rise, and many arid and semiarid regions will be drier. Human modifications of landscapes will also occur at an accelerated rate as developed areas increase in size and population density. We now...
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changes: A review of methods and research needs
Jon D. Pelletier1, A. Brad Murray2, Jennifer L. Pierce3
Drosophila suzukii (Spotted Wing Drosophila) has recently become a serious invasive pest of fruit crops in the USA, Canada, and Europe, leading to substantial economic losses. D. suzukii is a direct pest, ovipositing directly into ripe or ripening fruits; in contrast, other Drosophilids utilize decaying or blemished fruits and are...
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Using comparative genomics to develop a molecular diagnostic
Mixia osmundae (Basidiomycota, Pucciniomycotina) represents a monotypic class containing
an unusual fern pathogen with incompletely understood biology. We sequenced and analyzed
the genome of M. osmundae, focusing on genes that may provide some insight into its
mode of pathogenicity and reproductive biology.
Mixia osmundae has the smallest plant pathogenic basidiomycete...
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beads followed by end-repair, phosphorylation and A-tailing. Fragments were
ligated with HiSeq
Mixia osmundae (Basidiomycota, Pucciniomycotina) represents a monotypic class containing
an unusual fern pathogen with incompletely understood biology. We sequenced and analyzed
the genome of M. osmundae, focusing on genes that may provide some insight into its
mode of pathogenicity and reproductive biology.
Mixia osmundae has the smallest plant pathogenic basidiomycete...
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Toome, M., Ohm, R. A., Riley, R. W., James, T. Y., Lazarus, K. L., Henrissat, B.,
Albu, S., Boyd, A
Eukaryotic ribosome biogenesis involves ~200 assembly
factors, but how these contribute to ribosome
maturation is poorly understood. Here, we
identify a network of factors on the nascent 60S subunit
that actively remodels preribosome structure. At its hub is
Rsa4, a direct substrate of the force-generating ATPase
Rea1. We show that...
Eucalypts are the world’s most widely planted hardwood trees. Their outstanding diversity, adaptability and growth have
made them a global renewable resource of fibre and energy. We sequenced and assembled >94% of the 640-megabase
genome of Eucalyptus grandis. Of 36,376 predicted protein-coding genes, 34% occur in tandem duplications, the largest...
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Eucalyptus grandis
The genome of Eucalyptus grandis
Myburg, A. A., Grattapaglia, D., Tuskan, G. A
Significant seabird mortality on the Oregon (OR) and Washington (WA) coast in 2009 has been attributed
to a massive bloom of the dinoflagellate Akashiwo sanguinea (K. Hirasaka) G. Hansen & Ø. Moestrup.
Initial, albeit limited, observations suggested this bloom began in WA and reached OR waters through
southward transport. Here,...
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Northern California
current system in 2009
White, A. E., Watkins-Brandt, K. S., McKibben, S. M., Wood, A
Stream-dwelling species in the U.S. southern Appalachian Mountains region are particularly vulnerable to climate change and acidification. The objectives of this study were to quantify the spatial extent of contemporary suitable habitat for acid- and thermally sensitive aquatic species and to forecast future habitat loss resulting from expected temperature increases...
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length that was predicted to be: a) too warm (July mean daily maximum stream temperature (JMMST) >
22 oC
Stream-dwelling species in the U.S. southern Appalachian Mountains region are particularly vulnerable to climate change and acidification. The objectives of this study were to quantify the spatial extent of contemporary suitable habitat for acid- and thermally sensitive aquatic species and to forecast future habitat loss resulting from expected temperature increases...
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length that was predicted to be: a) too warm (July mean daily maximum stream water temperature (JMMST
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
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:
1418–1428.
24. Lee P, Zhang P, Herrmann A, Yang C, Xin H, Wang Z et al. Acetylated STAT3
is crucial
Sodium-ion batteries are emerging as a highly promising technology for large-scale energy
storage applications. However, it remains a significant challenge to develop an anode with
superior long-term cycling stability and high-rate capability. Here we demonstrate that the
Na⁺ intercalation pseudocapacitance in TiO₂/graphene nanocomposites enables high-rate
capability and long cycle life...
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batteries are emerging as a highly promising technology for large-scale energy
storage applications
Emerging application areas such as air pollution in megacities, wind energy, urban security, and operation of unmanned aerial vehicles have intensified scientific and societal interest in mountain meteorology. To address scientific needs and help improve the prediction of mountain weather, the U.S. Department of Defense has funded a research effort—the...
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. nadeau, e. kit, b. w. blomquiSt, P. Conry, r. S. CoPPerSmitH, e. Creegan, m. Felton,
a. graCHev, n
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
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., Lee et al., 2012; Mallmann and O’Neill, 2009]. If a more oxidized mantle source is not
involved, the
Circadian clocks coordinate physiological, neurological, and behavioral functions into circa 24 hour rhythms, and the
molecular mechanisms underlying circadian clock oscillations are conserved from Drosophila to humans. Clock oscillations
and clock-controlled rhythms are known to dampen during aging; additionally, genetic or environmental clock disruption
leads to accelerated aging and increased...
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diseases, such as
Alzheimer’s disease (AD), are associated with a decay of circadian rhythms, but it is not
The peptidyl nucleoside blasticidin S (BS) isolated from Streptomyces griseochromogenes was the first non-mercurial fungicide used on a large scale to prevent rice blast. In the biosynthesis of BS, leucylblasticidin S (LBS) was suggested as the penultimate metabolite with 20-fold less inhibitory activity than the final product BS. Incomplete conversion...
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fungicide used on a large scale to prevent rice blast. In the biosynthesis of BS,
leucylblasticidin S (LBS
Seascape ecology is an emerging discipline focused on understanding how features of the marine habitat influence the
spatial distribution of marine species. However, there is still a gap in the development of concepts and techniques for its
application in the marine pelagic realm, where there are no clear boundaries delimitating...
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Distribution
Alvarez-Berastegui, D., Ciannelli, L., Aparicio-Gonzalez, A., Reglero, P., Hidalgo,
M., et al
Interpretation of ice core trace gas records depends on an accurate understanding of the
processes that smooth the atmospheric signal in the firn. Much work has been done to understand the
processes affecting air transport in the open pores of the firn, but a paucity of data from air trapped...
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transport in the open pores of the firn, but a paucity of data from air trapped in
bubbles in the firn-ice
Gramene is a comparative information resource for plants that integrates data across diverse data domains. In this article,
we describe the development of a quantitative trait loci (QTL) database and illustrate how it can be used to facilitate
both the forward and reverse genetics research. The QTL database contains the...
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Gramene QTL database: development, content and applications
Ni, J., Pujar, A., Youens-Clark, K., Yap, I
Phytophthora infestans, the causal agent of late blight disease, has been reported in North America since the mid-nineteenth century. In the United States the lack of or very limited sexual reproduction has resulted in largely clonal populations of P. infestans. In 2010 and 2011, but not in 2012 or 2013,...
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and diverse genotypes
of P. infestans were detected in a region that centered around central New York
The exchange of carbon dioxide is a key measure of ecosystem metabolism and a critical intersection
between the terrestrial biosphere and the Earth’s climate. Despite the general agreement that
the terrestrial ecosystems in North America provide a sizeable carbon sink, the size and distribution
of the sink remain uncertain. We...
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in a temperate pine plantation
in southeastern Canada. Agric. For. Meteorol. 128, 223-241
Hydroacoustic data document the occurrence of 5 flare clusters and several single flares from which bubbles rise through the entire water column from an active seep site at 40 m water depth in the central North Sea. We investigated the difference in dissolved methane distributions along a 6 km transect...
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Seasonal methane accumulation and release from a gas
Biological invasions create complex ecological
and societal issues worldwide. Most of the
knowledge about invasions comes only from successful
invaders, but less is known about which processes
determine the differential success of invasions. In this
review, we develop a framework to identify the main
dimensions driving the success and failure...
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. A., ... & León-Muñoz, J. (2014). Differential invasion success of salmonids in
southern Chile
BACKGROUND: Triticum monococcum (2n) is a close ancestor of T. urartu, the A-genome progenitor of cultivated hexaploid
wheat, and is therefore a useful model for the study of components regulating photomorphogenesis in diploid wheat. In
order to develop genetic and genomic resources for such a study, we constructed genome-wide transcriptomes...
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monococcum
Samuel E. Fox1."¤a, Matthew Geniza1,2.", Mamatha Hanumappa1., Sushma Naithani1,3, Chris
The Leguminosae has emerged as a model for studying angiosperm plastome evolution because of its striking diversity of structural rearrangements and sequence variation. However, most of what is known about legume plastomes comes from few genera representing a subset of lineages in subfamily Papilionoideae. We investigate plastome evolution in subfamily...
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-Malki8,
Jamal S. M. Sabir7 & C. Donovan Bailey1
The Leguminosae has emerged as a model for studying
Large-scale poisoning events are common to scavenging bird species that forage communally,
many of which are in decline. To reduce the threat of poisoning and compensate for other persistent threats,
management, including supplemental feeding, is ongoing for many reintroduced and endangered vulture
populations. Through a longitudinal study of lead exposure...
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Kelly, T. R., Grantham, J., George, D., Welch, A., Brandt, J., Burnett, L. J.,
Sorenson, K. J., Johnson
The exchange of carbon dioxide is a key measure of ecosystem metabolism and a critical intersection
between the terrestrial biosphere and the Earth’s climate. Despite the general agreement that
the terrestrial ecosystems in North America provide a sizeable carbon sink, the size and distribution
of the sink remain uncertain. We...
Full Text:
Xiao, J., Ollinger, S. V., Frolking, S., Hurtt, G. C., Hollinger, D. Y., Davis, K. J., ... &
Suyker, A
Fungal hyphae are among the most highly polarized cells. Hyphal polarized
growth is supported by tip-directed transport of secretory vesicles, which accumulate temporarily
in a stratified manner in an apical vesicle cluster, the Spitzenkörper. The exocyst complex
is required for tethering of secretory vesicles to the apical plasma membrane. We...
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. W., Ludwig,
S., Beltrán-Aguilar, A., ... & Freitag, M. (2014). The Neurospora crassa exocyst
We use autonomous gas measurements to examine the metabolic balance (photosynthesis
minus respiration) of coastal Antarctic waters during the spring/summer growth season. Our observations
capture the development of a massive phytoplankton bloom and reveal striking variability in pCO₂ and
biological oxygen saturation (ΔO₂/Ar) resulting from large shifts in community metabolism...
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autonomous
pCO₂ and ΔO₂/Ar measurements
Tortell, P. D., Asher, E. C., Ducklow, H. W., Goldman, J. A. L
Embryonic diapause is a reproductive strategy widespread in the animal kingdom. This phenomenon is defined by a temporary arrest in blastocyst growth and metabolic activity within a quiescent uterus without implantation until the environmental and maternal milieu become favorable for pregnancy to progress. We found that uterine Msx expression persists...
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Limiting Inflammation in the Uterus
Cha, J., Burnum-Johnson, K. E., Bartos, A., Li, Y., Baker, E. S
BACKGROUND: We compared 24-hour waist-worn accelerometer wear time characteristics of 9-11 year old children
in the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE) to similarly aged U.S. children
providing waking-hours waist-worn accelerometer data in the 2003-2006 National Health and Nutrition Examination
Survey (NHANES).
METHODS: Valid cases were...
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Improving wear time compliance with a 24-hour waist
Cytogenetic chromosome maps offer molecular tools for genome analysis and clinical cytogenetics and are of particular
importance for species with difficult karyotypes, such as camelids (2n = 74). Building on the available human-camel zoo-fluorescence
in situ hybridization (FISH) data, we developed the first cytogenetic map for the alpaca (Lama pacos,...
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, Lee EJ, Agarwala R, Stallknecht-Rice E, et al.
2008. A 4,103 marker integrated physical and
Neurospora crassa has been for decades a principal model for filamentous
fungal genetics and physiology as well as for understanding
the mechanism of circadian clocks. Eukaryotic fungal and animal
clocks comprise transcription-translation-based feedback loops that
control rhythmic transcription of a substantial fraction of these transcriptomes,
yielding the changes in protein...
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., Dasgupta, A., Emerson, J. M., Zhou, X., Ringelberg, C. S., Knabe,
N., ... & Dunlap, J. C. (2014). Analysis
Research in warm-climate biomes has shown
that invasion by symbiotic dinitrogen (N₂)-fixing plants can
transform ecosystems in ways analogous to the transformations
observed as a consequence of anthropogenic, atmospheric
nitrogen (N) deposition: declines in biodiversity, soil
acidification, and alterations to carbon and nutrient cycling,
including increased N losses through nitrate...
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invaded
by n2-fixing species. In particular, the cold biomes stud-
ied here show both a strong potential
We investigated dissolved methane distributions along a 6 km transect crossing active seep sites at 40 m water depth in the central North Sea. These investigations were done under conditions of thermal stratification in summer (July 2013) and homogenous water column in winter (January 2014). Dissolved methane accumulated below the...
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Seasonal methane accumulation and release from a gas
BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States,
many eligible adults remain untreated. We projected the cost-effectiveness of treating
hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and
monitoring costs, costs...
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. Jaffe MG, Lee GA, Young JD, Sidney S,
Go AS. Improved blood pressure control
associated with a large
The filamentous fungus Neurospora crassa responds to light in complex ways. To thoroughly
study the transcriptional response of this organism to light, RNA-seq was used to analyze capped and
polyadenylated mRNA prepared from mycelium grown for 24 hr in the dark and then exposed to light for
0 (control) 15,...
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,†
Jay C. Dunlap,** Deborah Bell-Pedersen,* and Matthew S. Sachs*,1
*Department of Biology, Texas A&M
BACKGROUND: After 2 decades of focused efforts to eradicate polio, the impact of eradication activities on health
systems continues to be controversial. This study evaluated the impact of polio eradication activities on routine immunization
(RI) and primary healthcare (PHC).
METHODS: Quantitative analysis assessed the effects of polio eradication campaigns on...
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Primary Health Care: A Mixed-Methods Study
The Impact of Polio Eradication on Routine Immunization and
Dysregulation of Sonic hedgehog (Shh) signaling has been implicated in glioma pathogenesis. Yet, the role of this pathway
in gliomagenesis remains controversial because of the lack of relevant animal models. Using the cytokeratin 5 promoter, we
ectopically expressed a constitutively active zebrafish Smoothened (Smoa1) in neural progenitor cells and analyzed...
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expressed a constitutively active zebrafish Smoothened (Smoa1) in neural progenitor cells and analyzed
We present high-resolution measurements of carbon
monoxide (CO) concentrations from a shallow ice core
of the North Greenland Eemian Ice Drilling project (NEEM-
2011-S1). An optical-feedback cavity-enhanced absorption
spectrometer (OF-CEAS) coupled to a continuous melter
system performed continuous, online analysis during a fourweek
measurement campaign. This analytical setup generated
stable...
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High resolution measurements of carbon monoxide along a
The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation
to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight
control, i.e. cells respond to a signal to proliferate, and although most cells...
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,‡, Amedeo Amedei15,‡, Anna Maria Colacci16,‡,
Monica Vaccari16,‡, Chiara Mondello17,‡, A. Ivana Scovassi17
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species’ threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that...
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The PREDICTS database: a global database of how local
Much uncertainty exists about the state of the oceanic and atmospheric circulation in the tropical Pacific over the last glacial cycle. Studies have been hampered by the fact that sediment cores suitable for study were concentrated in the western and eastern parts of the tropical Pacific, with little information from...
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surface seawater
property gradients
Lynch‐Stieglitz, J., Polissar, P. J., Jacobel, A. W., Hovan, S. A
Global change and its associated temperature increase has directly or indirectly changed the distributions of hosts and
pathogens, and has affected host immunity, pathogen virulence and growth rates. This has resulted in increased disease in
natural plant and animal populations worldwide, including scleractinian corals. While the effects of temperature increase...
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Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression
Environmental contributions to cancer development are widely accepted, but only a fraction of all pertinent exposures
have probably been identified. Traditional toxicological approaches to the problem have largely focused on the effects of
individual agents at singular endpoints. As such, they have incompletely addressed both the pro-carcinogenic contributions
of environmentally...
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carcinogenesis?
Robey, R. B., Weisz, J., Kuemmerle, N., Salzberg, A. C., Berg, A., Brown, D.
G., ... & Ryan, E
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
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, and improves metabolic parameters in mouse models of obesity.
Gly-MCA is a selective high-affinity
BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States,
many eligible adults remain untreated. We projected the cost-effectiveness of treating
hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and
monitoring costs, costs...
Full Text:
MC, Thanataveerat A, et al. Cost-effectiveness of hypertension therapy accord-
ing to 2014 guidelines
Stream-dwelling species in the U.S. southern Appalachian Mountains region are particularly vulnerable to climate change and acidification. The objectives of this study were to quantify the spatial extent of contemporary suitable habitat for acid- and thermally sensitive aquatic species and to forecast future habitat loss resulting from expected temperature increases...
Full Text:
., Sullivan, T. J., Dolloff, C. A., Hessburg, P. F.,
Povak, N. A., ... & Sams, C. (2015). Downstream Warming
The ongoing retreat of glaciers globally is one of the clearest manifestations of recent global warming associated with rising greenhouse gas concentrations. By comparison, the importance of greenhouse gases in driving glacier retreat during the most recent deglaciation, the last major interval of global warming, is unclear due to uncertainties...
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Shakun, J. D., Clark, P. U., He, F., Lifton, N. A., Liu, Z., & Otto-Bliesner, B. L.
(2015). Regional and
Altimeter sea surface height (SSH) fields are analyzed to define and discuss the seasonal circulation
over the wide continental shelf in the SW Atlantic Ocean (27°–43°S) during 2001–2012. Seasonal variability
is low south of the Rio de la Plata (RdlP), where winds and currents remain equatorward for most of
the...
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:
27°–43°S
Strub, P. T., James, C., Combes, V., Matano, R. P., Piola, A. R., Palma, E. D., ...
& Ruiz
BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States,
many eligible adults remain untreated. We projected the cost-effectiveness of treating
hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and
monitoring costs, costs...
Full Text:
that allows appropriate data display. Each author should submit a separate
form and is responsible
BACKGROUND: After 2 decades of focused efforts to eradicate polio, the impact of eradication activities on health
systems continues to be controversial. This study evaluated the impact of polio eradication activities on routine immunization
(RI) and primary healthcare (PHC).
METHODS: Quantitative analysis assessed the effects of polio eradication campaigns on...
Full Text:
Immunization and Primary Health Care: A
Mixed-Methods Study
Web Supplement
TABLE OF CONTENTS
The ongoing retreat of glaciers globally is one of the clearest manifestations of recent global warming associated with rising greenhouse gas concentrations. By comparison, the importance of greenhouse gases in driving glacier retreat during the most recent deglaciation, the last major interval of global warming, is unclear due to uncertainties...
Full Text:
a younger population (J. Licciardi, pers. comm., 2012)
*****Following Licciradi et al. (2004