Honey bee colony losses are a major concern in the USA and across the globe. Long-term data on losses
are critical for putting yearly losses in context. US colony loss surveys have been conducted yearly since the winter
of 2006–2007. Here, we report the results from the eighth annual survey...
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We investigated DNA methylomes of pediatric B-cell
acute lymphoblastic leukemias (B-ALLs) using
whole-genome bisulfite sequencing and high-definition
microarrays, along with RNA expression
profiles. Epigenetic alteration of B-ALLs occurred in
two tracks: de novo methylation of small functional
compartments and demethylation of large intercompartmental
backbones. The deviations were exaggerated
in lamina-associated...
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Lee, S. T., Muench, M. O., Fomin, M. E., Xiao, J., Zhou, M., de Smith, A., ... &
Wiemels, J. L. (2015
Honey bee colony losses are a major concern in the USA and across the globe. Long-term data on losses
are critical for putting yearly losses in context. US colony loss surveys have been conducted yearly since the winter
of 2006–2007. Here, we report the results from the eighth annual survey...
Full Text:
in the USA
Lee, K. V., Steinhauer, N., Rennich, K., Wilson, M. E., Tarpy, D. R., Caron, D.
M
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
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cells.
Carcinogenesis 2009; 30: 1416–1432.
11. Lee JI, Nian H, Cooper AJ, Sinha R, Dai J, Bisson WH et
Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However, the identity of the ligand(s) responsible for such AHR-mediated activation within the gut remains to be firmly established....
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Microbiol 7, 42 (2007).
3. Lee, J. H. & Lee, J. Indole as an intercellular signal in microbial communities
The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation
to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight
control, i.e. cells respond to a signal to proliferate, and although most cells...
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., Hultman, T., Karamouzis, M.
V., ... & Bisson, W. H. (2015). The potential for chemical mixtures from the
We present high-resolution measurements of carbon
monoxide (CO) concentrations from a shallow ice core
of the North Greenland Eemian Ice Drilling project (NEEM-
2011-S1). An optical-feedback cavity-enhanced absorption
spectrometer (OF-CEAS) coupled to a continuous melter
system performed continuous, online analysis during a fourweek
measurement campaign. This analytical setup generated
stable...
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., Chappellaz, J., Rhodes, R. H., Stowasser, C., Blunier, T., McConnell, J.
R., ... & Romanini, D. (2014). High
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
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. Amin4, William H. Bisson5, Yulan Liu3, Oksana Gavrilova6, Andrew D. Patterson7 &
Frank J. Gonzalez1
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
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the differentiation of
hydrous melts
Jenner, F. E., Hauri, E. H., Bullock, E. S., König, S., Arculus