BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
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Humans
Heald, A. E., Charleston, J. S., Iversen, P. L., Warren, T. K., Saoud, J. B.,
Al-Ibrahim, M
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
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Frances E. Jennera,b*, Erik H. Haurib, Emma S. Bullockc, Stephan Königd, Richard J. Arculuse, John
A
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
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the differentiation of
hydrous melts
Jenner, F. E., Hauri, E. H., Bullock, E. S., König, S., Arculus
Exotic species dominate many communities; however the functional significance of species’ biogeographic origin remains highly contentious. This debate is fuelled in part by the lack of globally replicated, systematic data assessing the relationship between species provenance, function and response to perturbations. We examined the abundance of native and exotic plant...
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X X X X
Cleland, Elsa E. X X X
Davies, Kendi X X X
Firn, Jennifer X X X
Exotic species dominate many communities; however the functional significance of species’ biogeographic origin remains highly contentious. This debate is fuelled in part by the lack of globally replicated, systematic data assessing the relationship between species provenance, function and response to perturbations. We examined the abundance of native and exotic plant...
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response to nutrient
enrichment and herbivores in global grasslands
Seabloom, E. W., Borer, E. T
BACKGROUND: After 2 decades of focused efforts to eradicate polio, the impact of eradication activities on health
systems continues to be controversial. This study evaluated the impact of polio eradication activities on routine immunization
(RI) and primary healthcare (PHC).
METHODS: Quantitative analysis assessed the effects of polio eradication campaigns on...
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, J., Gopinath, R., ... &
Nuttall, E. (2014). The Impact of Polio Eradication on Routine Immunization
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species’ threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that...
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Armbrecht20, Badrul Azhar21,22, Adri�an B. Azpiroz23, Lander Baeten24,25, Andr�as B�aldi26, John
E. Banks27
Non-structural carbohydrates (NSC) in plant tissue are frequently quantified to make inferences about plant responses to environmental conditions. Laboratories publishing estimates of NSC of woody plants use many different methods to evaluate NSC. We asked whether NSC estimates in the recent literature could be quantitatively compared among studies. We also...
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., Pinkard, E. A., Ryan, M. G., Tissue, D. T., Baggett, L. S., Adams,
H. D., ... & Gibon, Y. (2015). Non
Neurospora crassa has been for decades a principal model for filamentous
fungal genetics and physiology as well as for understanding
the mechanism of circadian clocks. Eukaryotic fungal and animal
clocks comprise transcription-translation-based feedback loops that
control rhythmic transcription of a substantial fraction of these transcriptomes,
yielding the changes in protein...
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, Xiaoying Zhoua, Carol S. Ringelberga, Nicole Knabea,
Anna M. Lipzenb, Erika A. Lindquistb, Christopher G
BACKGROUND: After 2 decades of focused efforts to eradicate polio, the impact of eradication activities on health
systems continues to be controversial. This study evaluated the impact of polio eradication activities on routine immunization
(RI) and primary healthcare (PHC).
METHODS: Quantitative analysis assessed the effects of polio eradication campaigns on...
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Investigator; Matthew Landis; Matthew Luck;
Frank Pont; Lisa Emmer; Nicole Grohoski
CARE (Administration