Index Catalog // ScholarsArchive@OSU

Creator:: Baßler, Jochen, Paternoga, Helge, Holdermann, Iris, Nyarko, Afua, Clark, Sarah A., Barbar, Elisar, and et al.
Abstract:: Eukaryotic ribosome biogenesis involves ~200 assembly factors, but how these contribute to ribosome maturation is poorly understood. Here, we identify a network of factors on the nascent 60S subunit that actively remodels preribosome structure. At its hub is Rsa4, a direct substrate of the force-generating ATPase Rea1. We show that...
Full Text:: second helix shows variability in its orientation and length. The Nsa2 confor- mation may be stabilized

Creator:: Ni, Junjian, Pujar, Anuradha, Youens-Clark, Ken, Jaiswal, Pankaj, and et al.
Abstract:: Gramene is a comparative information resource for plants that integrates data across diverse data domains. In this article, we describe the development of a quantitative trait loci (QTL) database and illustrate how it can be used to facilitate both the forward and reverse genetics research. The QTL database contains the...
Full Text:: provided by ontology terms. Mutations identified in functional genomics populations and association

Creator:: Long, Dani M., Blake, Matthew R., Dutta, Sudeshna, Kotwica-Rolinska, Joanna, Giebultowicz, Jadwiga M., and et al.
Abstract:: Circadian clocks coordinate physiological, neurological, and behavioral functions into circa 24 hour rhythms, and the molecular mechanisms underlying circadian clock oscillations are conserved from Drosophila to humans. Clock oscillations and clock-controlled rhythms are known to dampen during aging; additionally, genetic or environmental clock disruption leads to accelerated aging and increased...
Full Text:: Alzheimer's Disease-Like Symptoms in Drosophila Relationships between the Circadian System and Alzheimer’s

Creator:: Liu, Qing, Spitsbergen, Jan M., Cariou, Ronan, and et al.
Abstract:: The goal of this project was to investigate the effects and possible developmental disease implication of chronic dietary TCDD exposure on global gene expression anchored to histopathologic analysis in juvenile zebrafish by functional genomic, histopathologic and analytic chemistry methods. Specifically, juvenile zebrafish were fed Biodiet starter with TCDD added at...
Full Text:: We used individual fish to perform the microarray experiments and assess biologic variability in

Creator:: Febria, Catherine M., Hosen, Jacob D., Crump, Byron C., and et al.
Abstract:: Microbial communities are responsible for the bulk of biogeochemical processing in temporary headwater streams, yet there is still relatively little known about how community structure and function respond to periodic drying. Moreover, the ability to sample temporary habitats can be a logistical challenge due to the limited capability to measure...
Full Text:: of microbial communities in temporary streams to natural and human-induced fluctuations in flow

Creator:: Faïn, X., Chappellaz, J., Rhodes, R. H., and et al.
Abstract:: We present high-resolution measurements of carbon monoxide (CO) concentrations from a shallow ice core of the North Greenland Eemian Ice Drilling project (NEEM- 2011-S1). An optical-feedback cavity-enhanced absorption spectrometer (OF-CEAS) coupled to a continuous melter system performed continuous, online analysis during a fourweek measurement campaign. This analytical setup generated stable...
Full Text:: complete understanding of the modern CO budget and its evolution in relation to past climate variability

Creator:: Kang, Y., Nian, H., Rajendran, P., Löhr, C. V., Bisson, W. H., Williams, D. E., and et al.
Abstract:: Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Full Text:: - stein–Taybi syndrome, and other congenital abnormalities.32–35 Loss-of-function HDAC8 mutations in six

Creator:: Ju, B., Chen, W., Spitsbergen, J. M., and et al.
Abstract:: Dysregulation of Sonic hedgehog (Shh) signaling has been implicated in glioma pathogenesis. Yet, the role of this pathway in gliomagenesis remains controversial because of the lack of relevant animal models. Using the cytokeratin 5 promoter, we ectopically expressed a constitutively active zebrafish Smoothened (Smoa1) in neural progenitor cells and analyzed...
Full Text:: expressed a constitutively active zebrafish Smoothened (Smoa1) in neural progenitor cells and analyzed

Creator:: Wu, Cheng, Yang, Fei, Smith, Kristina M., Bredeweg, Erin L., Freitag, Michael, and et al.
Abstract:: The filamentous fungus Neurospora crassa responds to light in complex ways. To thoroughly study the transcriptional response of this organism to light, RNA-seq was used to analyze capped and polyadenylated mRNA prepared from mycelium grown for 24 hr in the dark and then exposed to light for 0 (control) 15,...
Full Text:: expression be- tween 60 and 120 min in the light, the so-called late light-induced genes. Cluster 3 was

Creator:: Soyer, Jessica L., El Ghalid, Mennat, Glaser, Nicolas, Connolly, Lanelle R., Freitag, Michael, and et al.
Abstract:: Plant pathogens secrete an arsenal of small secreted proteins (SSPs) acting as effectors that modulate host immunity to facilitate infection. SSP-encoding genes are often located in particular genomic environments and show waves of concerted expression at diverse stages of plant infection. To date, little is known about the regulation of...
Full Text:: -isochores are gene-poor, enriched in TEs truncated and degenerated by Repeat-Induced Point mutation (RIP

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