Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
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colon cancer cells
HDAC8 and STAT3 repress BMF gene activity in colon cancer cells
Kang, Y., Nian, H
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
BACKGROUND: We compared 24-hour waist-worn accelerometer wear time characteristics of 9-11 year old children
in the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE) to similarly aged U.S. children
providing waking-hours waist-worn accelerometer data in the 2003-2006 National Health and Nutrition Examination
Survey (NHANES).
METHODS: Valid cases were...
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-worn accelerometer protocol in the International Study of Childhood Obesity, Lifestyle and the
Circadian clocks coordinate physiological, neurological, and behavioral functions into circa 24 hour rhythms, and the
molecular mechanisms underlying circadian clock oscillations are conserved from Drosophila to humans. Clock oscillations
and clock-controlled rhythms are known to dampen during aging; additionally, genetic or environmental clock disruption
leads to accelerated aging and increased...
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Alzheimer's Disease-Like Symptoms in Drosophila
Relationships between the Circadian System and Alzheimer’s
Sodium-ion batteries are emerging as a highly promising technology for large-scale energy
storage applications. However, it remains a significant challenge to develop an anode with
superior long-term cycling stability and high-rate capability. Here we demonstrate that the
Na⁺ intercalation pseudocapacitance in TiO₂/graphene nanocomposites enables high-rate
capability and long cycle life...
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Na+ intercalation pseudocapacitance in graphene-coupled
Plant pathogens secrete an arsenal of small secreted proteins (SSPs) acting as effectors that modulate host immunity to
facilitate infection. SSP-encoding genes are often located in particular genomic environments and show waves of concerted
expression at diverse stages of plant infection. To date, little is known about the regulation of...
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Epigenetic Control of Effector Gene Expression in the
The filamentous fungus Neurospora crassa responds to light in complex ways. To thoroughly
study the transcriptional response of this organism to light, RNA-seq was used to analyze capped and
polyadenylated mRNA prepared from mycelium grown for 24 hr in the dark and then exposed to light for
0 (control) 15,...
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in Neurospora crassa
Genome-Wide Characterization of Light-Regulated Genes in
Neurospora crassa
Microbial communities are responsible for the bulk of biogeochemical processing in temporary headwater streams, yet there is still relatively little known about how community structure and function respond to periodic drying. Moreover, the ability to sample temporary habitats can be a logistical challenge due to the limited capability to measure...
Phytophthora infestans, the causal agent of late blight disease, has been reported in North America since the mid-nineteenth century. In the United States the lack of or very limited sexual reproduction has resulted in largely clonal populations of P. infestans. In 2010 and 2011, but not in 2012 or 2013,...
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An Ephemeral Sexual Population of Phytophthora infestans in
Pathogens often have negative effects on wildlife populations, and disease management strategies are important for mitigating opportunities for pathogen transmission. Bovine tuberculosis (Mycobacterium bovis; BTB) is widespread among African buffalo (Syncerus caffer) populations in southern Africa, and strategies for managing this disease vary. In two high profile parks, Kruger National...
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selection: evidence
Signatures of natural and unnatural selection: evidence from an
immune system gene in