We investigated DNA methylomes of pediatric B-cell
acute lymphoblastic leukemias (B-ALLs) using
whole-genome bisulfite sequencing and high-definition
microarrays, along with RNA expression
profiles. Epigenetic alteration of B-ALLs occurred in
two tracks: de novo methylation of small functional
compartments and demethylation of large intercompartmental
backbones. The deviations were exaggerated
in lamina-associated...
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Lee, S. T., Muench, M. O., Fomin, M. E., Xiao, J., Zhou, M., de Smith, A., ... &
Wiemels, J. L. (2015
Eucalypts are the world’s most widely planted hardwood trees. Their outstanding diversity, adaptability and growth have
made them a global renewable resource of fibre and energy. We sequenced and assembled >94% of the 640-megabase
genome of Eucalyptus grandis. Of 36,376 predicted protein-coding genes, 34% occur in tandem duplications, the largest...
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, Kelly Vining16, Vindhya Amarasinghe16, Martin Ranik16,
Sushma Naithani17,18, Justin Elser17, Alexander E
A feedback between decomposition and litter chemical composition occurs with decomposition altering composition that in turn influences the decomposition rate. Elucidating the temporal pattern of chemical composition is vital to understand this feedback, but the effects of plant species and climate on chemical changes remain poorly understood, especially over multiple...
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Li, Y., Chen, N., Harmon, M. E., Li, Y., Cao, X., Chappell, M. A., & Mao, J. (2015).
Plant Species
Fidelity to migratory destinations is an important driver of connectivity in marine and avian species. Here we assess the role of maternally directed learning of migratory habitats, or migratory culture, on the population structure of the endangered Australian and New Zealand southern right whale. Using DNA profiles, comprising mitochondrial DNA...
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Carroll, E. L., Baker, C. S., Watson, M., Alderman, R., Bannister, J., Gaggiotti, O.
E., ... & Harcourt
Inherited bone marrow failure syndromes (IBMFS) including Fanconi anemia, dyskeratosis congenita, Diamond-Blackfan anemia, and Shwachman-Diamond syndrome are rare genetic disorders characterized by hematologic complications and increased risk of cancer. Patients and their families likely experience obstacles in obtaining sufficient health information given their disorders’ rarity. To investigate this possibility, we...
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Syndromes
Hamilton, J. G., Hutson, S. P., Frohnmayer, A. E., Han, P. K., Peters, J. A., Carr,
A. G
We investigated dissolved methane distributions along a 6 km transect crossing active seep sites at 40 m water depth in the central North Sea. These investigations were done under conditions of thermal stratification in summer (July 2013) and homogenous water column in winter (January 2014). Dissolved methane accumulated below the...
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., ... & Helmke,
E. (2015). Seasonal methane accumulation and release from a gas emission site
in the central
The exchange of carbon dioxide is a key measure of ecosystem metabolism and a critical intersection
between the terrestrial biosphere and the Earth’s climate. Despite the general agreement that
the terrestrial ecosystems in North America provide a sizeable carbon sink, the size and distribution
of the sink remain uncertain. We...
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. E. (2014). Data-driven diagnostics of terrestrial carbon dynamics over
North America. Agricultural
Background: Prenatal mercury (Hg) exposure is associated with adverse child neurobehavioral
outcomes. Because Hg can interfere with placental functioning and cross the placenta to target the
fetal brain, prenatal Hg exposure can inhibit fetal growth and development directly and indirectly.
Objectives: We examined potential associations between prenatal Hg exposure assessed...
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Mercury and
Adverse Neurobehavioral Outcomes
Maccani, J., Koestler, D. C., Lester, B., Houseman, E. A
Hydroacoustic data document the occurrence of 5 flare clusters and several single flares from which bubbles rise through the entire water column from an active seep site at 40 m water depth in the central North Sea. We investigated the difference in dissolved methane distributions along a 6 km transect...
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., ... & Helmke,
E. (2014). Seasonal methane accumulation and release from a gas emission site
in the central
Early Holocene summer warmth drove dramatic Greenland ice sheet (GIS) retreat. Subsequent
insolation-driven cooling caused GIS margin readvance to late Holocene maxima, from which ice margins
are now retreating. We use ¹⁰Be surface exposure ages from four locations between 69.4°N and 61.2°N to
date when in the early Holocene south...
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. Schmidt, F. S. Anslow, J. M. Licciardi, and E. A. Obbink (2008), Rapid early Holocene
deglaciation of the