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Filtering by: Creator Nguyen, Bao Creator Fahlgren, Noah Creator Carrington, James C.

Computational and analytical framework for small RNA profiling by high-throughput sequencing

Creator:

Fahlgren, Noah, Sullivan, Christopher M., Kasschau, Krisitin D., Chapman, Elisabeth J., Cumbie, Jason S., Montgomery, Taiowa A., Gilbert, Sunny D., Dasenko, Mark, Backman, Tyler W. H., Givan, Scott A., and Carrington, James C.

Abstract:

The advent of high-throughput sequencing (HTS) methods has enabled direct approaches to quantitatively profile small RNA populations. However, these methods have been limited by several factors, including representational artifacts and lack of established statistical methods of analysis. Furthermore, massive HTS data sets present new problems related to data processing and...

Resource Type:

Article

Full Text:

://www.rnajournal.org. ACKNOWLEDGMENTS We thank Goretti Nguyen for assistance with small RNA library preparations, and
Garcia-RuizHernanBotanyPlantPathologyRolesProgramming.pdf

Creator:

Garcia-Ruiz, Hernan, Carbonell, Alberto, Hoyer, J. Steen, Fahlgren, Noah, Takeda, Atsushi, Giampetruzzi, Annalisa, Lowery, Nicholas, Carrington, James C., and et al.

Abstract:

In eukaryotes, ARGONAUTE proteins (AGOs) associate with microRNAs (miRNAs), short interfering RNAs (siRNAs), and other classes of small RNAs to regulate target RNA or target loci. Viral infection in plants induces a potent and highly specific antiviral RNA silencing response characterized by the formation of virus-derived siRNAs. Arabidopsis thaliana has...