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Filtering by: Subject Drug-nutrient interactions Creator Fan, Ying

Effect of pharmaceuticals and natural products on multidrug resistance mediatedtransport in Caco-2 and MDCKII-MDR1 drug transport models

Creator:

Fan, Ying

Abstract:

This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...

Resource Type:

Dissertation

Full Text:

reduced the Papp efflux of CSA and increased the Papp absorption of digoxin. The drug-diet interaction