Index Catalog // ScholarsArchive@OSU

Expression of a Structural Protein of the Mycovirus FgV-ch9 Negatively Affects the Transcript Level of a Novel Symptom Alleviation Factor and Causes Virus Infection-Like Symptoms in Fusarium graminearum

Creator:: Bormann, Joerg, Heinze, Cornelia, Blum, Christine, Mentges, Michael, Brockmann, Anke, Alder, Arne, Landt, Svenja Kim, Josephson, Brian, Indenbirken, Daniela, Spohn, Michael, Plitzko, Birte, Loesgen, Sandra, Freitag, Michael, and Schaefer, Wilhelm
Abstract:: Infections of fungi by mycoviruses are often symptomless but sometimes also fatal, as they perturb sporulation, growth, and, if applicable, virulence of the fungal host. Hypovirulence-inducing mycoviruses, therefore, represent a powerful means to defeat fungal epidemics on crop plants. Infection with Fusarium graminearum virus China 9 (FgV-ch9), a double-stranded RNA...
Resource Type:: Article
Full Text:: Anke Brockmann,a Arne Alder,a Svenja Kim Landt,a Brian Josephson,b Daniela Indenbirken,c Michael Spohn

The kinetochore interaction network (KIN) of ascomycetes

Creator:: Freitag, Michael
Abstract:: Chromosome segregation relies on coordinated activity of a large assembly of proteins, the kinetochore interaction network (KIN). How conserved the underlying mechanisms driving the epigenetic phenomenon of centromere and kinetochore assembly and maintenance are remains unclear, even though various eukaryotic models have been studied. More than 50 different proteins, many...
Resource Type:: Article

Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon

Creator:: Wang, Yizhou, Smith, Kristina M., Taylor, John W., Freitag, Michael, and Stajich, Jason E.
Abstract:: Genome defense likely evolved to curtail the spread of transposable elements and invading viruses. A combination of effective defense mechanisms has been shown to limit colonization of the Neurospora crassa genome by transposable elements. A novel DNA transposon named Sly1-1 was discovered in the genome of the most widely used...
Resource Type:: Article
Full Text:: Transposon Yizhou Wang,*,† Kristina M. Smith,‡ John W. Taylor,§ Michael Freitag,‡ and Jason E. Stajich*,1

Histone modifications rather than the novel regional centromeres of Zymoseptoria tritici distinguish core and accessory chromosomes

Creator:: Schotanus, Klaas, Soyer, Jessica L., Connolly, Lanelle R., Grandaubert, Jonathan, Happel, Petra, Smith, Kristina M., Freitag, Michael, and Stukenbrock, Eva H.
Abstract:: Background: Supernumerary chromosomes have been found in many organisms. In fungi, these “accessory” or “dispensable” chromosomes are present at different frequencies in populations and are usually characterized by higher repetitive DNA content and lower gene density when compared to the core chromosomes. In the reference strain of the wheat pathogen,...
Resource Type:: Article
Full Text:: , Lanelle R. Connolly3, Jonathan Grandaubert1,4,5, Petra Happel1, Kristina M. Smith3, Michael Freitag3* and

Deletion of gene clusters to identify novel secondary metabolites in Fusarium graminearum

Creator:: Husk, Jacob, Connolly, Lanelle, and Freitag, Michael
Abstract:: CGRB Fall Conference 2015
Resource Type:: Poster
Full Text:: Michael Freitag PmeISwaI SecMet cluster DNA Scheme 3: Capture whole clusters with plasmid marker+ 5

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection

Creator:: Roquis, David, Lepesant, Julie M. J., Picard, Marion A. L., Freitag, Michael, Parrinello, Hugues, Groth, Marco, Emans, Rémi, Cosseau, Céline, and Grunau, Christoph
Abstract:: Background: Chromatin structure can control gene expression and can define specific transcription states. For example, bivalent methylation of histone H3K4 and H3K27 is linked to poised transcription in vertebrate embryonic stem cells (ESC). It allows them to rapidly engage specific developmental pathways. We reasoned that non-vertebrate metazoans that encounter a...
Resource Type:: Article
Full Text:: . A., Freitag, M., Parrinello, H., Groth, M., ... & Grunau, C. (2015). The Epigenome of Schistosoma

Increase in cellular triacylglycerol content and emergence of large ER-associated lipid droplets in the absence of CDP-DG synthase function

Creator:: He, Yue, Yam, Candice, Pomraning, Kyle, Chin, Jacqueline S. R., Yew, Joanne Y., Freitag, Michael, and Oliferenko, Snezhana
Abstract:: Excess fatty acids and sterols are stored as triacylglycerols and sterol esters in specialized cellular organelles, called lipid droplets. Understanding what determines the cellular amount of neutral lipids and their packaging into lipid droplets is of fundamental and applied interest. Using two species of fission yeast, we show that cycling...
Resource Type:: Article
Full Text:: ER-associated lipid droplets in the absence of CDP-DG synthase function He, Y., Yam, C., Pomraning

Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential

Creator:: Hurley, Jennifer M., Dasgupta, Arko, Emerson, Jillian M., Smith, Kristina M., Freitag, Michael, Zhou, Xiaoying, Ringelberg, Carol S., Knabe, Nicole, Lipzen, Anna, Linduist, Erika A., Daum, Christopher G., Barry, Kerrie W., Grigoriev, Igor V., Galagan, James E., Bell-Pederson, Deborah, Cheng, Chao, Loros, Jennifer J., and Dunlap, Jay C.
Abstract:: Neurospora crassa has been for decades a principal model for filamentous fungal genetics and physiology as well as for understanding the mechanism of circadian clocks. Eukaryotic fungal and animal clocks comprise transcription-translation-based feedback loops that control rhythmic transcription of a substantial fraction of these transcriptomes, yielding the changes in protein...
Resource Type:: Article

Genome-Wide Characterization of Light-Regulated Genes in Neurospora crassa

Creator:: Wu, Cheng, Yang, Fei, Smith, Kristina M., Peterson, Matthew, Dekhang, Rigzin, Zhang, Ying, Zucker, Jeremy, Bredeweg, Erin L., Mallappa, Chandrashekara, Zhou, Xiaoying, Lyubetskaya, Anna, Townsend, Jeffrey P., Galagan, James E., Freitag, Michael, Dunlap, Jay C., Bell-Pedersen, Deborah, and Sachs, Matthew S.
Abstract:: The filamentous fungus Neurospora crassa responds to light in complex ways. To thoroughly study the transcriptional response of this organism to light, RNA-seq was used to analyze capped and polyadenylated mRNA prepared from mycelium grown for 24 hr in the dark and then exposed to light for 0 (control) 15,...
Resource Type:: Article

Heterochromatin Controls γH2A Localization in Neurospora crassa

Creator:: Sasaki, Takahiko, Lynch, Kelsey L., Mueller, Caitlin V., Friedman, Steven, Freitag, Michael, and Lewis, Zachary A.
Abstract:: In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine. The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
Resource Type:: Article

ScholarsArchive@OSU

Expression of a Structural Protein of the Mycovirus FgV-ch9 Negatively Affects the Transcript Level of a Novel Symptom Alleviation Factor and Causes Virus Infection-Like Symptoms in Fusarium graminearum

The kinetochore interaction network (KIN) of ascomycetes

Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon

Histone modifications rather than the novel regional centromeres of Zymoseptoria tritici distinguish core and accessory chromosomes

Deletion of gene clusters to identify novel secondary metabolites in Fusarium graminearum

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection

Increase in cellular triacylglycerol content and emergence of large ER-associated lipid droplets in the absence of CDP-DG synthase function

Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential

Genome-Wide Characterization of Light-Regulated Genes in Neurospora crassa

Heterochromatin Controls γH2A Localization in Neurospora crassa

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