Index Catalog // ScholarsArchive@OSU

Creator:: Coleman, Daniel J., Garcia, Gloria, Hyter, Stephen, Jang, Hyo Sang, Chagani, Sharmeen, Liang, Xiaobo, Larue, Lionel, Ganguli-Indra, Gitali, and Indra, Arup K.
Abstract:: Understanding the molecular mechanisms of ultraviolet (UV) induced melanoma formation is becoming crucial with more reported cases each year. Expression of type II nuclear receptor Retinoid-X-Receptor α (RXRα) is lost during melanoma progression in humans. Here, we observed that in mice with melanocyte-specific ablation of RXRα and RXRβ, melanocytes attract...

Creator:: Coleman, Daniel J., Garcia, Gloria, Hyter, Stephen, Jang, Hyo Sang, Chagani, Sharmeen, Liang, Xiaobo, Larue, Lionel, Ganguli-Indra, Gitali, and Indra, Arup K.
Abstract:: Understanding the molecular mechanisms of ultraviolet (UV) induced melanoma formation is becoming crucial with more reported cases each year. Expression of type II nuclear receptor Retinoid-X-Receptor α (RXRα) is lost during melanoma progression in humans. Here, we observed that in mice with melanocyte-specific ablation of RXRα and RXRβ, melanocytes attract...

Creator:: Guha, Gunjan, Lu, Wanli, Li, Shan, Liang, Xiaobo, Kulesz-Martin, Molly F., Mahmud, Taifo, Indra, Arup Kumar, and Ganguli-Indra, Gitali
Abstract:: Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de-6MSA-7-demethyl-7- deoxypactamycin (TM-025) and 7-demethyl-7-deoxypactamycin (TM-026), in head and neck squamous cell carcinoma...
Resource Type:: Article

Creator:: Coleman, Daniel J., Garcia, Gloria, Hyter, Stephen, Jang, Hyo Sang, Chagani, Sharmeen, Liang, Xiaobo, Larue, Lionel, Ganguli-Indra, Gitali, and Indra, Arup K.
Abstract:: Understanding the molecular mechanisms of ultraviolet (UV) induced melanoma formation is becoming crucial with more reported cases each year. Expression of type II nuclear receptor Retinoid-X-Receptor α (RXRα) is lost during melanoma progression in humans. Here, we observed that in mice with melanocyte-specific ablation of RXRα and RXRβ, melanocytes attract...
Resource Type:: Article

Creator:: Zhang, Ling-juan, Bhattacharya, Shreya, Leid, Mark, Ganguli-Indra, Gitali, and Indra, Arup K.
Abstract:: Epidermal morphogenesis results from a delicate balance between keratinocyte proliferation and differentiation, and this balance is perturbed upon deletion of transcription factor Ctip2. Here we demonstrate that Ctip2, in a cell autonomous manner, controls keratinocyte proliferation and cytoskeletal organization, and regulates the onset and maintenance of differentiation in keratinocytes in...
Resource Type:: Article

Creator:: Wang, Zhixing, Zhang, Ling-juan, Guha, Gunjan, Li, Shan, Kyrylkova, Kateryna, Kioussi, Chrissa, Leid, Mark, Ganguli-Indra, Gitali, and Indra, Arup K.
Abstract:: Background: Ctip2 is crucial for epidermal homeostasis and protective barrier formation in developing mouse embryos. Selective ablation of Ctip2 in epidermis leads to increased transepidermal water loss (TEWL), impaired epidermal proliferation, terminal differentiation, as well as altered lipid composition during development. However, little is known about the role of Ctip2...
Resource Type:: Article

Creator:: Liang, Xiaobo, Bhattacharya, Shreya, Bajaj, Gaurav, Guha, Gunjan, Wang, Zhixing, Jang, Hyo-Sang, Leid, Mark, Indra, Arup Kumar, and Ganguli-Indra, Gitali
Abstract:: Background: COUP-TF interacting protein 2 [(Ctip2), also known as Bcl11b] is an important regulator of skin homeostasis, and is overexpressed in head and neck cancer. Ctip2(ep-/-) mice, selectively ablated for Ctip2 in epidermal keratinocytes, exhibited impaired terminal differentiation and delayed epidermal permeability barrier (EPB) establishment during development, similar to what...
Resource Type:: Article

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