Index Catalog // ScholarsArchive@OSU

Creator:: Jacobs, Dakota C. and Giebultowicz, Jadwiga M.
Abstract:: Mammalian female reproduction requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from neurons in the preoptic area (POA) of the hypothalamus, initiated by elevated estradiol (E₂). Rising E₂ activates a subset ofsexually dimorphic Kisspeptin neurons in the female, located in the anteroventralperiventricular nuclei (AVPV). Conversely, E₂ negative feedback is mediated by...

Creator:: Jacobs, Dakota C. and Giebultowicz, Jadwiga M.
Abstract:: Mammalian female reproduction requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from neurons in the preoptic area (POA) of the hypothalamus, initiated by elevated estradiol (E₂). Rising E₂ activates a subset ofsexually dimorphic Kisspeptin neurons in the female, located in the anteroventralperiventricular nuclei (AVPV). Conversely, E₂ negative feedback is mediated by...

Creator:: Blake, Matthew R., Holbrook, Scott D., Kotwica-Rolinska, Joanna, Chow, Eileen S., Kretzschmar, Doris, and Giebultowicz, Jadwiga M.
Abstract:: Alzheimer's disease (AD) is a neurodegenerative disease characterized by severe cognitive deterioration. While causes of AD pathology are debated, a large body of evidence suggests that increased cleavage of Amyloid Precursor Protein (APP) producing the neurotoxic Amyloid-β (Aβ) peptide plays a fundamental role in AD pathogenesis. One of the detrimental...
Resource Type:: Article

Creator:: Rakshit, Kuntol, Krishnan, Natraj, Guzik, Elzbieta M., Pyza, Elzbieta, and Giebultowicz, Jadwiga M.
Abstract:: Circadian clocks maintain temporal homeostasis by generating daily output rhythms in molecular, cellular, and physiological functions. Output rhythms, such as sleep/wake cycles and hormonal fluctuations, tend to deteriorate during aging in humans, rodents, and fruit flies. However, it is not clear whether this decay is caused by defects in the...
Resource Type:: Article

Creator:: Krishnan, Natraj, Rakshit, Kuntol, Chow, Eileen S., Wentzell, Jill S., Kretzschmar, Doris, and Giebultowicz, Jadwiga M.
Abstract:: Circadian clocks generate rhythms in molecular, cellular, physiological, and behavioral processes. Recent studies suggest that disruption of the clock mechanism accelerates organismal senescence and age-related pathologies in mammals. Impaired circadian rhythms are observed in many neurological diseases; however, it is not clear whether loss of rhythms is the cause or...
Resource Type:: Article

Creator:: Krishnan, Natraj, Kretzchmar, Doris, Rakshit, Kuntol, Chow, Eileen, and Giebultowicz, Jadwiga M.
Abstract:: There is increasing evidence that aging is affected by biological (circadian) clocks – the internal mechanisms that coordinate daily changes in gene expression, physiological functions and behavior with external day/night cycles. Recent data suggest that disruption of the mammalian circadian clock results in accelerated aging and increased age‐related pathologies such...
Resource Type:: Article

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