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Filtering by: Creator Chung, Chuen-shang Creator Giebultowicz, Jadwiga M.

Effects of Aging on the Molecular Circadian Oscillations in Drosophila

Creator:

Rakshit, Kuntol, Krishnan, Natraj, Guzik, Elzbieta M., Pyza, Elzbieta, and Giebultowicz, Jadwiga M.

Abstract:

Circadian clocks maintain temporal homeostasis by generating daily output rhythms in molecular, cellular, and physiological functions. Output rhythms, such as sleep/wake cycles and hormonal fluctuations, tend to deteriorate during aging in humans, rodents, and fruit flies. However, it is not clear whether this decay is caused by defects in the...

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(Allada & Chung, 2010; Bae & Edery, 2006). Whereas the core transcriptional clock is well understood in
Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

Creator:

Beaver, Laura M., Klichko, Vladimir I., Chow, Eileen S., Kotwica-Rolinska, Joanna, Williamson, Marisa, Orr, William C., Radyuk, Svetlana N., and Giebultowicz, Jadwiga M.

Abstract:

Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular mechanisms that govern such fluctuations remained unknown. To address this question, we used the model species Drosophila, which has a...

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. 6. Allada R, Chung BY (2010) Circadian organization of behavior and physiology in Drosophila