Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Has journal ACS Applied Materials & Interfaces Creator Golbek, Thaddeus W. Degree Field Chemical Engineering

Probing the Biophysical interactions of Anti-Microbial Peptide WLBU2 Using Model Membrane Systems

Creator:

Golbek, Thaddeus W.

Abstract:

WLBU2 is an engineered cationic amphiphilic peptide that targets Gram-positive and Gram-negative bacteria, and envelopes endotoxin while avoiding other cell types. The exact mechanism of how WLBU2 targets, binds, and disrupts bacterial cell membranes is still not completely known. Thus, the overall goal of this investigation is to determine the...

Resource Type:

Masters Thesis

Full Text:

interface specific spectroscopy tools to probe the biophysical interactions between the peptide and both
Probing Structure, Selectivity, and Orientation of Biomolecules to Cell Membranes by Sum Frequency Generation

Creator:

Golbek, Thaddeus W.

Abstract:

Cell membranes act as barriers against unwanted movement of ions and biomolecules and are complex surfaces littered with protein channels, ion channels, cholesterol, and a myriad of different proteins. While this surface is extremely well studied, there is still much we do not know. The work in this dissertation demonstrates...

Resource Type:

Dissertation

Full Text:

at the air-water interface was used at the model membrane for observing the peptide interactions