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Creator:: Nguyen, Anh Tuan, Koh, Vivien, Spitsbergen, Jan M., and Gong, Zhiyuan
Abstract:: Here we report a new transgenic expression system by combination of liver-specific expression, mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure of mifepristone to induce permanent genomic recombination mediated by...
Resource Type:: Article

Creator:: Nguyen, Anh Tuan, Koh, Vivien, Spitsbergen, Jan M., and Gong, Zhiyuan
Abstract:: Here we report a new transgenic expression system by combination of liver-specific expression, mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure of mifepristone to induce permanent genomic recombination mediated by...
Full Text:: expression in transgenic zebrafish Anh Tuan Nguyen 1, 2 , Vivien Koh 1 , Jan M. Spitsbergen 2

Creator:: Nguyen, Anh Tuan, Koh, Vivien, Spitsbergen, Jan M., and Gong, Zhiyuan
Abstract:: Here we report a new transgenic expression system by combination of liver-specific expression, mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure of mifepristone to induce permanent genomic recombination mediated by...
Full Text:: Anh Tuan Nguyen Vivien Koh Jan M. Spitsbergen Zhiyuan

Creator:: Sun, Lili, Anh Tuan Nguyen, Spitsbergen, Jan M., and Gong, Zhiyuan
Abstract:: Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it remains unclear about the oncogenicity of...
Full Text:: Mutation Sun, L., Nguyen, A. T., Spitsbergen, J. M., & Gong, Z. (2015). Myc-Induced Liver Tumors in

Creator:: Sun, Lili, Anh Tuan Nguyen, Spitsbergen, Jan M., and Gong, Zhiyuan
Abstract:: Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it remains unclear about the oncogenicity of...

Creator:: Sun, Lili, Anh Tuan Nguyen, Spitsbergen, Jan M., and Gong, Zhiyuan
Abstract:: Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it remains unclear about the oncogenicity of...
Resource Type:: Article

Creator:: Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Parinov, Serguei, and Gong, Zhiyuan
Abstract:: Because Ras signaling is frequently activated by major hepatocellular carcinoma etiological factors, a transgenic zebrafish constitutively expressing the kras(V12) oncogene in the liver was previously generated by our laboratory. Although this model depicted and uncovered the conservation between zebrafish and human liver tumorigenesis, the low tumor incidence and early mortality...
Resource Type:: Article
Full Text:: promoter (Nguyen et al., 2011). Although this model has revealed several molecular mechanisms underlying

Creator:: Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Lam, Siew Hong, Mathavan, Sinnakaruppan, Parinov, Serguei, and Gong, Zhiyuan
Abstract:: Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma (HCC) being the most common type. Aberrant Ras signaling has been implicated in the development and progression of human HCC, but a complete understanding of the molecular mechanisms of this protein in hepatocarcinogenesis remains elusive. In this...
Resource Type:: Article
Full Text:: robust liver tumorigenesis in transgenic zebrafish Anh Tuan Nguyen1,2, Alexander Emelyanov2, Chor Hui

Creator:: Chew, Ti Weng, Liu, Xing Jun, Liu, Lihui, Spitsbergen, Jan M., Gong, Zhiyuan, and Low, Boon Chuan
Abstract:: RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell growth and tissue development through their distinct signaling pathways. While much has been learnt about their individual functions in both cell and animal models, the physiological and pathophysiological consequences of their signaling crosstalk in multi-cellular context...
Full Text:: motility. Nat Struct Mol Biol. 2007 Mar;14(3):215-23. 16. Chen JC, Zhuang S, Nguyen TH, Boss GR, Pilz RB

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