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Filtering by: Creator Martin, Lloyd Creator Gross, Michael K. License Attribution 3.0 United States

Population-Specific Regulation of Chmp2b by Lbx1 during Onset of Synaptogenesis in Lateral Association Interneurons

Creator:

Xu, Jun, Nonogaki, Mariko, Madhira, Ravi, Ma, Hsiao-Yen, Hermanson, Ola, Kioussi, Chrissa, and Gross, Michael K.

Abstract:

Chmp2b is closely related to Vps2, a key component of the yeast protein complex that creates the intralumenal vesicles of multivesicular bodies. Dominant negative mutations in Chmp2b cause autophagosome accumulation and neurodegenerative disease. Loss of Chmp2b causes failure of dendritic spine maturation in cultured neurons. The homeobox gene Lbx1 plays...

Resource Type:

Article