Index Catalog // ScholarsArchive@OSU

The impact of aminated surface ligands and silica shells on the stability, uptake, and toxicity of engineered silver nanoparticles

Creator:: Bonventre, Josephine A., Pryor, Joseph B., Harper, Bryan J., and Harper, Stacey L.
Abstract:: Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle...
Resource Type:: Article

Impacts of chemical modification on the toxicity of diverse nanocellulose materials to developing zebrafish

Creator:: Harper, Bryan J., Clendaniel, Alicea, Sinche, Federico, Way, Daniel, Hughes, Michael, Schardt, Jenna, Simonsen, John, Stefaniak, Aleksandr B., and Harper, Stacey L.
Abstract:: Cellulose is an abundant and renewable resource currently being investigated for utility in nanomaterial form for various promising applications ranging from medical and pharmaceutical uses to mechanical reinforcement and biofuels. The utility of nanocellulose and wide implementation ensures increasing exposure to humans and the environment as nanocellulose-based technologies advance. Here,...
Resource Type:: Article
Full Text:: investigate how differences in aspect ratio and changes to surface chemistry, as well as synthesis methods

BonventreJosephineEMTImpactAminatedSurface.pdf

Creator:: Bonventre, Josephine A., Pryor, Joseph B., Harper, Bryan J., and Harper, Stacey L.
Abstract:: Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle...
Full Text:: Inherent nanomaterial characteristics, com- position, surface chemistry, and primary particle size, are

BonventreJosephineEMTImpactAminatedSurface_SupportingInformation.zip

Creator:: Bonventre, Josephine A., Pryor, Joseph B., Harper, Bryan J., and Harper, Stacey L.
Abstract:: Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle...

Comparative toxicological assessment of PAMAM and thiophosphoryl dendrimers using embryonic zebrafish

Creator:: Pryor, Joseph B., Harper, Bryan J., and Harper, Stacey L.
Abstract:: Dendrimers are well-defined, polymeric nanomaterials currently being investigated for biomedical applications such as medical imaging, gene therapy, and tissue targeted therapy. Initially, higher generation (size) dendrimers were of interest because of their drug carrying capacity. However, increased generation was associated with increased toxicity. The majority of studies exploring dendrimer toxicity...
Resource Type:: Article
Full Text:: broad range of dendrimers. Keywords: nanomaterials, in vivo, toxicity, generation, surface chemistry

HarperBryanEMTImpactSurfaceLigands.pdf

Creator:: Harper, Bryan, Sinche, Federico, Wu, Rosina Ho, Gowrishankar, Meenambika, Marquart, Grant, Mackiewicz, Marilyn, and Harper, Stacey L.
Abstract:: Gold nanoparticles (AuNPs) are increasingly used in biomedical applications, hence understanding the processes that affect their biocompatibility and stability are of significant interest. In this study, we assessed the stability of peptide-capped AuNPs and used the embryonic zebrafish (Danio rerio) as a vertebrate system to investigate the impact of synthesis...
Full Text:: chelation and optical imaging applications. Surface chemistry has been shown to play a role in the uptake

MarcheseRobinsonHowShouldCompleteness.pdf

Creator:: Marchese Robinson, Richard L., Lynch, Iseult, Peijnenburg, Willie, Rumble, John, Klaessig, Fred, Marquardt, Clarissa, Rauscher, Hubert, Puzyn, Tomasz, Purian, Ronit, Åberg, Christoffer, Karcher, Sandra, Vriens, Hanne, Hoet, Peter, Hoover, Mark D., Hendren, Christine Ogilvie, and Harper, Stacey L.
Abstract:: Nanotechnology is of increasing significance. Curation of nanomaterial data into electronic databases offers opportunities to better understand and predict nanomaterials’ behaviour. This supports innovation in, and regulation of, nanotechnology. It is commonly understood that curated data need to be sufficiently complete and of sufficient quality to serve their intended purpose....
Full Text:: Fermi 2749, 21027 Ispra (VA), Italy iLaboratory of Environmental Chemistry, University of Gdansk, Wita

Informatics and Standards for Nanomedicine Technology

Creator:: Thomas, Dennis G., Klaessig, Fred, Harper, Stacey L., Fritts, Martin, Hoover, Mark D., Gaheen, Sharon, Stokes, Todd H., Reznik-Zellen, Rebecca, Freund, Elaine T., Klemm, Juli D., Paik, David S., and Baker, Nathan A.
Abstract:: There are several issues to be addressed concerning the management and effective use of information (or data), generated from nanotechnology studies in biomedical research and medicine. These data are large in volume, diverse in content, and are beset with gaps and ambiguities in the description and characterization of nanomaterials. In...
Resource Type:: Article
Full Text:: , molecular weight, shape, physical state, surface chemistry, purity, solubility and relaxivity; data from in

MarcheseRobinsonHowShouldCompletenessSuppInfo.pdf

Creator:: Marchese Robinson, Richard L., Lynch, Iseult, Peijnenburg, Willie, Rumble, John, Klaessig, Fred, Marquardt, Clarissa, Rauscher, Hubert, Puzyn, Tomasz, Purian, Ronit, Åberg, Christoffer, Karcher, Sandra, Vriens, Hanne, Hoet, Peter, Hoover, Mark D., Hendren, Christine Ogilvie, and Harper, Stacey L.
Abstract:: Nanotechnology is of increasing significance. Curation of nanomaterial data into electronic databases offers opportunities to better understand and predict nanomaterials’ behaviour. This supports innovation in, and regulation of, nanotechnology. It is commonly understood that curated data need to be sufficiently complete and of sufficient quality to serve their intended purpose....
Full Text:: contaminants as well as size and surface chemistry “must” have been provided), details regarding the

NEIMiner: nanomaterial environmental impact data miner

Creator:: Tang, Kaizhi, Liu, Xiong, Harper, Stacey L., Steevens, Jeffery A., and Xu, Roger
Abstract:: As more engineered nanomaterials (eNM) are developed for a wide range of applications, it is crucial to minimize any unintended environmental impacts resulting from the application of eNM. To realize this vision, industry and policymakers must base risk management decisions on sound scientific information about the environmental fate of eNM,...
Resource Type:: Article
Full Text:: chemistry (eg, reactivity, redox potential, surface charge), solubility (eg, hydrophobicity

ScholarsArchive@OSU

The impact of aminated surface ligands and silica shells on the stability, uptake, and toxicity of engineered silver nanoparticles

Impacts of chemical modification on the toxicity of diverse nanocellulose materials to developing zebrafish

BonventreJosephineEMTImpactAminatedSurface.pdf

BonventreJosephineEMTImpactAminatedSurface_SupportingInformation.zip

Comparative toxicological assessment of PAMAM and thiophosphoryl dendrimers using embryonic zebrafish

HarperBryanEMTImpactSurfaceLigands.pdf

MarcheseRobinsonHowShouldCompleteness.pdf

Informatics and Standards for Nanomedicine Technology

MarcheseRobinsonHowShouldCompletenessSuppInfo.pdf

NEIMiner: nanomaterial environmental impact data miner

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