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Creator:: Siddens, Lisbeth K., Krueger, Sharon K., Henderson, Marilyn C., and Williams, David E.
Abstract:: Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2 and 3, expressed in Sf9 insect microsomes, released 30-50% of O₂ consumed as H₂O₂ upon addition of NADPH. Addition of substrate had little effect on H₂O₂ production. Two common FMO2 (the major...
Full Text:: Hydrogen Peroxide Siddens, L. K., Krueger, S. K., Henderson, M. C., & Williams, D. E. (2014). Mammalian

Creator:: Siddens, Lisbeth K., Krueger, Sharon K., Henderson, Marilyn C., and Williams, David E.
Abstract:: Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2 and 3, expressed in Sf9 insect microsomes, released 30-50% of O₂ consumed as H₂O₂ upon addition of NADPH. Addition of substrate had little effect on H₂O₂ production. Two common FMO2 (the major...

Creator:: Siddens, Lisbeth K., Krueger, Sharon K., Henderson, Marilyn C., and Williams, David E.
Abstract:: Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2 and 3, expressed in Sf9 insect microsomes, released 30-50% of O₂ consumed as H₂O₂ upon addition of NADPH. Addition of substrate had little effect on H₂O₂ production. Two common FMO2 (the major...
Resource Type:: Article

Creator:: Henderson, Marilyn C., Siddens, Lisbeth K., Krueger, Sharon K., Stevens, J. Fred, Kedzie, Karen, Fang, Ken, Heidelbaugh, Todd, Phong Nguyen, Chow, Ken, Garst, Michael, Gil, Daniel, and Williams, David E.
Abstract:: Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...

Creator:: Henderson, Marilyn C., Siddens, Lisbeth K., Krueger, Sharon K., Stevens, J. Fred, Kedzie, Karen, Fang, Ken, Heidelbaugh, Todd, Phong Nguyen, Chow, Ken, Garst, Michael, Gil, Daniel, and Williams, David E.
Abstract:: Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Full Text:: 150 200 250 300 m/z 100 75 50 25 0 R e la ti v e I n te n s it y

Creator:: Henderson, Marilyn C., Siddens, Lisbeth K., Krueger, Sharon K., Stevens, J. Fred, Kedzie, Karen, Fang, Ken, Heidelbaugh, Todd, Phong Nguyen, Chow, Ken, Garst, Michael, Gil, Daniel, and Williams, David E.
Abstract:: Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Full Text:: 280 300 m/z 100 75 50 25 0 R e la ti v e I n te n s it y ( % ) 229

Creator:: Henderson, Marilyn C., Siddens, Lisbeth K., Krueger, Sharon K., Stevens, J. Fred, Kedzie, Karen, Fang, Ken, Heidelbaugh, Todd, Phong Nguyen, Chow, Ken, Garst, Michael, Gil, Daniel, and Williams, David E.
Abstract:: Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Full Text:: /z 100 75 50 25 0 R e la ti v e I n te n s it y ( % ) 229 231 232

Creator:: Henderson, Marilyn C., Siddens, Lisbeth K., Krueger, Sharon K., Stevens, J. Fred, Kedzie, Karen, Fang, Ken, Heidelbaugh, Todd, Phong Nguyen, Chow, Ken, Garst, Michael, Gil, Daniel, and Williams, David E.
Abstract:: Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...

Creator:: Henderson, Marilyn C., Siddens, Lisbeth K., Krueger, Sharon K., Stevens, J. Fred, Kedzie, Karen, Fang, Ken, Heidelbaugh, Todd, Phong Nguyen, Chow, Ken, Garst, Michael, Gil, Daniel, and Williams, David E.
Abstract:: Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...

Creator:: Henderson, Marilyn C., Siddens, Lisbeth K., Krueger, Sharon K., Stevens, J. Fred, Kedzie, Karen, Fang, Ken, Heidelbaugh, Todd, Phong Nguyen, Chow, Ken, Garst, Michael, Gil, Daniel, and Williams, David E.
Abstract:: Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Full Text:: , K., Fang, W. K., ... & Williams, D. E. (2014). Flavin-containing monooxygenase S-oxygenation of a

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