The promise of epigenome-wide association studies (EWAS) and cancer specific somatic changes in improving our understanding of cancer coupled with the decreasing cost and increasing coverage of DNA methylation microarrays, has brought about a surge in the use of these technologies. Here, we aim to provide both a review of...
Background: Prenatal mercury (Hg) exposure is associated with adverse child neurobehavioral
outcomes. Because Hg can interfere with placental functioning and cross the placenta to target the
fetal brain, prenatal Hg exposure can inhibit fetal growth and development directly and indirectly.
Objectives: We examined potential associations between prenatal Hg exposure assessed...
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Chen HY, Yeh JI, Hong CJ, Chen CH. 2005. Mutation
analysis of ARVCF gene on chromosome 22q11 as
a
Background: There is increasing epidemiologic evidence that arsenic exposure in utero, even at low levels found throughout much of the world, is associated with adverse reproductive outcomes and may contribute to long-term health effects. Animal models, in vitro studies, and human cancer data suggest that arsenic may induce epigenetic alterations,...
BACKGROUND: The impact of cell-composition effects in analysis of DNA methylation data is now widely appreciated.
With the availability of a reference data set consisting of DNA methylation measurements on isolated cell types, it is
possible to impute cell proportions and adjust for them, but there is increasing interest in...