Index Catalog // ScholarsArchive@OSU

Creator:: Warren, Travis K., Whitehouse, Chris A., Wells, Jay, Welch, Lisa, Heald, Alison E., Charleston, Jay S., Sazani, Pete, Reid, St. Patrick, Iversen, Patrick L., and Bavari, Sina
Abstract:: Ebola viruses (EBOV) cause severe disease in humans and nonhuman primates with high mortality rates and continue to emerge in new geographic locations, including several countries in West Africa, the site of a large ongoing outbreak. Phosphorodiamidate morpholino oligomers (PMOs) are synthetic antisense molecules that are able to target mRNAs...
Resource Type:: Article
Full Text:: . K., Whitehouse, C. A., Wells, J., Welch, L., Heald, A. E., Charleston, J. S., ... & Bavari, S

Creator:: Heald, Alison E., Charleston, Jay S., Iversen, Patrick L., Warren, Travis K., Saoud, Jay B., Al-Ibrahim, Mohamed, Wells, Jay, Warfield, Kelly L., Swenson, Dana L., Welch, Lisa S., Sazani, Peter, Wong, Michael, Berry, Diane, Kaye, Edward M., and Bavari, Sina
Abstract:: BACKGROUND: AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS: We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Resource Type:: Article and Presentation

Creator:: Heald, Alison E., Charleston, Jay S., Iversen, Patrick L., and et al.
Abstract:: BACKGROUND: AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS: We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:: ., Travis K. Warren, Ph.D., Jay B. Saoud, Ph.D., Mohamed Al-Ibrahim, M.B., Ch.B., Jay Wells, B.S., Kelly L

Creator:: Heald, Alison E., Charleston, Jay S., Iversen, Patrick L., and et al.
Abstract:: BACKGROUND: AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS: We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:: ., Patrick L. Iversen, Ph.D., Travis K. Warren, Ph.D., Jay B. Saoud, Ph.D., Mohamed Al-Ibrahim, M.B., Ch.B

Creator:: Heald, Alison E., Charleston, Jay S., Iversen, Patrick L., and et al.
Abstract:: BACKGROUND: AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS: We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...

ScholarsArchive@OSU