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Creator:: Heald, Alison E., Charleston, Jay S., Iversen, Patrick L., and et al.
Abstract:: BACKGROUND: AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS: We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:: product. Alison E. Heald, MD Senior Director, Clinical De\'eloprnent Sarepta Therapeutics, Inc. 2 15

Creator:: Heald, Alison E., Charleston, Jay S., Iversen, Patrick L., and et al.
Abstract:: BACKGROUND: AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS: We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:: Information Section 1. 1. Given Name (First Name) Alison E. 2. Surname (Last Name) Heald 4. Are you the

Creator:: Heald, Alison E., Charleston, Jay S., Iversen, Patrick L., and et al.
Abstract:: BACKGROUND: AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS: We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...

Creator:: Heald, Alison E., Charleston, Jay S., Iversen, Patrick L., and et al.
Abstract:: BACKGROUND: AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS: We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:: Nonhuman Primates and Humans Alison E. Heald, M.D., Jay S. Charleston, Ph.D., Patrick L. Iversen, Ph.D

Creator:: Heald, Alison E., Charleston, Jay S., Iversen, Patrick L., and et al.
Abstract:: BACKGROUND: AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS: We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:: for Marburg Virus in Nonhuman Primates and Humans Alison E. Heald, M.D., Jay S. Charleston, Ph.D

Creator:: Warren, Travis K., Whitehouse, Chris A., Wells, Jay, Welch, Lisa, Heald, Alison E., Charleston, Jay S., Sazani, Pete, Reid, St. Patrick, Iversen, Patrick L., and Bavari, Sina
Abstract:: Ebola viruses (EBOV) cause severe disease in humans and nonhuman primates with high mortality rates and continue to emerge in new geographic locations, including several countries in West Africa, the site of a large ongoing outbreak. Phosphorodiamidate morpholino oligomers (PMOs) are synthetic antisense molecules that are able to target mRNAs...
Resource Type:: Article
Full Text:: Lethal Ebola Virus Infection Travis K. Warren,a Chris A. Whitehouse,a Jay Wells,a Lisa Welch,a Alison E

Creator:: Heald, Alison E., Iversen, Patrick L., Saoud, Jay B., Sazani, Peter, Charleston, Jay S., Axtelle, Tim, Wong, Michael, Smith, William B., Vutikullird, Apinya, and Kaye, Edward
Abstract:: Two identical single-ascending-dose studies evaluated the safety and pharmacokinetics (PK) of AVI-6002 and AVI-6003, two experimental combinations of phosphorodiamidate morpholino oligomers with positive charges (PMOplus) that target viral mRNA encoding Ebola virus and Marburg virus proteins, respectively. Both AVI-6002 and AVI-6003 were found to suppress disease in virus-infected nonhuman primates...
Resource Type:: Article
Full Text:: -Dose Studies Alison E. Heald,a Patrick L. Iversen,a,d Jay B. Saoud,a Peter Sazani,a Jay S. Charleston

Creator:: Heald, Alison E., Charleston, Jay S., Iversen, Patrick L., Warren, Travis K., Saoud, Jay B., Al-Ibrahim, Mohamed, Wells, Jay, Warfield, Kelly L., Swenson, Dana L., Welch, Lisa S., Sazani, Peter, Wong, Michael, Berry, Diane, Kaye, Edward M., and Bavari, Sina
Abstract:: BACKGROUND: AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS: We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Resource Type:: Article and Presentation

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