Index Catalog // ScholarsArchive@OSU

Creator:: Gretes, Michael C., Poole, Leslie B., and Karplus, P. Andrew
Abstract:: Significance: Parasite survival and virulence relies on effective defenses against reactive oxygen and nitrogen species produced by the host immune system. Peroxiredoxins (Prxs) are ubiquitous enzymes now thought to be central to such defenses and, as such, have potential value as drug targets and vaccine antigens. Recent Advances: Plasmodial and...
Resource Type:: Article
Full Text:: efficiency (kcat/Km) values of 10 5 M - 1s - 1. Such reported catalytic rates, much lower than those of

Creator:: Perkins, Arden, Poole, Leslie B., and Karplus, P. Andrew
Abstract:: Peroxiredoxins (Prxs) make up an ancient family of enzymes that are the predominant peroxidases for nearly all organisms and play essential roles in reducing hydrogen peroxide, organic hydroperoxides, and peroxynitrite. Even between distantly related organisms, the core protein fold and key catalytic residues related to its cysteine-based catalytic mechanism have...
Resource Type:: Article
Full Text:: proteins by reducing 4 hydroperoxides and peroxynitrite4. With catalytic rates of ~107 M-1 s-1 and an

Creator:: Perkins, Arden, Nelson, Kimberly J., Parsonage, Derek, Poole, Leslie B., and Karplus, P. Andrew
Abstract:: Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes that play dominant roles in regulating peroxide levels within cells. These enzymes, often present at high levels and capable of rapidly clearing peroxides, display a remarkable array of variations in their oligomeric states and susceptibility to regulation by hyperoxidative inactivation...
Resource Type:: Article
Full Text:: the reaction. Typical units for a second order rate constant are M-1 s-1. . 1 2 3 4

ScholarsArchive@OSU