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Filtering by: Subject Drug-nutrient interactions Creator Lafollette, Sharron E.

Modification of the acute effects of ethanol or acetaldehyde on drug metabolism by ascorbic acid, thiamine, or cysteine in vivo

Creator:

LaFollette, Sharron E.

Abstract:

The inhibition of mixed-function oxidase (MFO) activity by ethanol or acetaldehyde was examined in vivo by monitoring changes in salivary half-life of antipyrine or aminopyrine in adult male Sprague-Dawley rats. Ethanol (1-6 g/kg, po) or acetaldehyde (4-8 mmol/kg, ip) was administered 20 minutes prior to antipyrine (100 mg/kg, ip) or...

Resource Type:

Dissertation

Full Text:

acetaldehyde on drug metabolism by ascorbic acid, thiamine, or cysteine in vivo AN ABSTRACT OF THE THESIS OF