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Improving the post-thaw processing of cryopreserved red blood cells using a combined approach of mathematical modeling and microfluidics

Creator:

Lusianti, Ratih E.

Abstract:

This study lays the groundwork on potential techniques that could be employed to improve the post-thaw wash processing of cryopreserved human red blood cells. Transfusion of red blood cells is one of the most commonly practiced procedures in clinical medicine. Millions of red blood cell units are transfused to patients...

Resource Type:

Dissertation

Full Text:

. Abstract approved: ____________________________________________________ Adam Z. Higgins This
Removal of cryoprotectant with the use of a microseparation device

Creator:

Lusianti, Ratih E.

Abstract:

Cryoprotectants (CPAs) such as glycerol and dimethyl sulfoxide (DMSO) are commonly used during cryopreservation of cell based therapeutics. Although these additives are beneficial during freezing, it is often desirable to remove them before infusion into a patient. Currently, the most common method for CPA removal is by centrifugation. This method...

Resource Type:

Masters Thesis

Full Text:

. Abstract approved:_________________________________________________________________ Adam Z