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Structure and proposed mechanism of L-α-glycerophosphate oxidase from Mycoplasma pneumoniae

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Elkhal, Callia K., Kean, Kelsey M., Parsonage, Derek, Maenpuen, Somchart, Chaiyen, Pimchai, Claiborne, Al, and Karplus, P. Andrew

Abstract:

The formation of hydrogen peroxide (H₂O₂) by the FAD-dependent α-glycerophosphate oxidase (GlpO), is important for the pathogenesis of Streptococcus pneumoniae and Mycoplasma pneumoniae. The structurally known GlpO from Streptococcus sp. (SspGlpO) is similar to the pneumococcal protein (SpGlpO) and provides a guide for drug design against that target. However, M....

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-glycerophosphate oxidase from Mycoplasma pneumoniae Callia K. Elkhal,1# Kelsey Kean,1# Derek Parsonage,2
Kinetic Mechanism of L-α-Glycerophosphate Oxidase from Mycoplasma pneumoniae

Creator:

Maenpuen, Somchart, Watthaisong, Pratchaya, Supon, Pacharee, Sucharitakul, Jeerus, Parsonage, Derek, Karplus, P. Andrew, Claiborne, Al, and Chaiyen, Pimchai

Abstract:

L-α-glycerophosphate oxidase is an FAD-dependent enzyme that catalyzes the oxidation of L-α-glycerophosphate (Glp) by molecular oxygen to generate dihydroxyacetone phosphate (DHAP) and hydrogen peroxide (H₂O₂). The catalytic properties of the recombinant His₆-GlpO from Mycoplasma pneumoniae (His₆-MpGlpO) were investigated with transient and steady-state kinetics and ligand binding. The results indicate that...

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Article

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, Pacharee Supon1, Jeerus Sucharitakul2, 4 Derek Parsonage3, P. Andrew Karplus4, Al Claiborne3and Pimchai

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Structure and proposed mechanism of L-α-glycerophosphate oxidase from Mycoplasma pneumoniae

Kinetic Mechanism of L-α-Glycerophosphate Oxidase from Mycoplasma pneumoniae

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