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The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro

Creator:

Marley, Kevin, Helfand, Stuart C., Edris, Wade A., Mata, John E., Gitelman, Alix I., Medlock, Jan, and Seguin, Bernard

Abstract:

Background: Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6–12 months despite these treatments. Taurolidine, a derivative of taurine, has...

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alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro Marley et al
Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma

Creator:

Marley, Kevin, Helfand, Stuart C., Simpson, Jennifer, Mata, John E., Tracewell, William G., Brownlee, Lisa, Bracha, Shay, and Séguin, Bernard

Abstract:

Background: Osteosarcoma in dogs and humans share many similarities and the dog has been described as an excellent model to study this disease. The median survival in dogs has not improved in the last 25 years. Taurolidine has been shown to be cytotoxic to canine and human osteosarcoma in vitro....

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for dogs with osteosarcoma Marley et al. Journal of Experimental & Clinical Cancer Research 2013, 32