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  • Investigation of the roles of viral proteinases in the vaccinia virus life cycle

    Creator:
    Page, Jessica M.
    Abstract:
    An inducible, mutant virus, designated vvtetO:I7L/G1L, was used to study the morphogenic proteolysis step of the vaccinia virus life cycle. The vvtetO:I7L/G1L controlled the expression of two genes, I7L, a cysteine proteinase, and G1L, a putative metalloproteinase. These proteins are involved in the maturation of viral core proteins, p4a, p4b,...
    Resource Type:
    Honors College Thesis
    Full Text:
    Dennis Hruby An inducible, mutant virus, designated vvtetO:I7L/G1L, was used to study the morphogenic