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Filtering by: Creator Ryu, Jeong-Gon Creator Poole, Leslie B. Creator Nelson, Kimberly J.

Evaluating peroxiredoxin sensitivity towards inactivation by peroxide substrates

Creator:

Nelson, Kimberly J., Parsonage, Derek, Karplus, P. Andrew, and Poole, Leslie B.

Abstract:

Peroxiredoxins (Prxs) are very effective peroxide reducing enzymes, but also are susceptible to being oxidatively inactivated by their own substrates. The level of sensitivity to such hyperoxidation varies depending both on the enzyme involved and the type of peroxide substrate. For some Prxs, the hyperoxidation has physiological relevance, so it...

Resource Type:

Article

Full Text:

inducible (Jeong et al., 2012) and important for the survival of cells under low (10-20 M) peroxide