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Effects of Aging on the Molecular Circadian Oscillations in Drosophila

Creator:

Rakshit, Kuntol, Krishnan, Natraj, Guzik, Elzbieta M., Pyza, Elzbieta, and Giebultowicz, Jadwiga M.

Abstract:

Circadian clocks maintain temporal homeostasis by generating daily output rhythms in molecular, cellular, and physiological functions. Output rhythms, such as sleep/wake cycles and hormonal fluctuations, tend to deteriorate during aging in humans, rodents, and fruit flies. However, it is not clear whether this decay is caused by defects in the...

Resource Type:

Article

Full Text:

(Allada & Chung, 2010; Bae & Edery, 2006). Whereas the core transcriptional clock is well understood in
Exploring functional links between circadian clocks, neurodegeneration, and aging in Drosophila melanogaster

Creator:

Rakshit, Kuntol

Abstract:

Circadian clocks are endogenous molecular mechanisms that coordinate daily rhythms in gene expression, cellular activities, and physiological functions with external day/night cycles. Breakdown of circadian rhythms such as sleep/wake cycles is associated with the onset of several neurological diseases; however, it is not clear whether disruption of rhythms is a...

Resource Type:

Dissertation

Full Text:

, physiological and behavioral rhythms (Schibler 2007; Allada & Chung 2010). Disruption of circadian rhythms by