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Mycobacterium avium Biofilm Attenuates Mononuclear Phagocyte Function by Triggering Hyperstimulation and Apoptosis during Early Infection

Creator:

Rose, Sasha J. and Bermudez, Luiz E.

Abstract:

Mycobacterium avium subsp. hominissuis is an opportunistic human pathogen that has been shown to form biofilm in vitro and in vivo. Biofilm formation in vivo appears to be associated with infections in the respiratory tract of the host. The reasoning behind how M. avium subsp. hominissuis biofilm is allowed to...

Resource Type:

Article

Full Text:

- ous gift from Kathleen Eisenach (Little Rock, AR). Prior to biofilm for- mation, bacteria were
Further Understanding Mycobacterial Biofilms and Their Interaction with the Host

Creator:

Rose, Sasha J.

Abstract:

Respiratory infections caused by nontuberculous mycobacteria (NTM), especially Mycobacterium avium, can lead to progressive, recurrent disease that is refractory to therapy. Bacterial biofilms are intrinsically resistant to a variety of stressors and pressures, including host killing mechanisms and antibiotic therapy. Though it is becoming increasingly evident that NTM biofilms are...

Resource Type:

Dissertation