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Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

Creator:

Ryder, Matthew P.

Abstract:

While hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] (PEO-PPO-PEO) surfactant Pluronic® F108 are highly resistant to plasma protein adsorption, the antimicrobial peptide nisin has been observed to adsorb in multilayer quantities at such surfaces, and the PEO chains themselves suggested to inhibit nisin exchange by blood proteins. But...

Resource Type:

Masters Thesis

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80,000 of these taking place in an ICU. The cost of the ICU infections ranges between $296 million and
Functionalization of Surfaces with Nisin in a Polyethylene Oxide Brush Layer

Creator:

Ryder, Matthew P.

Abstract:

Infections in hospitals account for over 100,000 deaths per year. These infections occur at the hospital from complications following bacterial adhesion to intravenous catheters, coronary stents and other implanted devices. Another common problem is protein adsorption to the surface of the device and subsequent blood clotting. Methods for combating these...

Resource Type:

Honors College Thesis

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Biopharma, without whom this project would not have been conducted in the first place. Their initial
Binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2 at interfaces

Creator:

Ryder, Matthew P.

Abstract:

Passage of blood through a sorbent device for removal of bacteria and endotoxin by specific binding with immobilized, membrane-active, bactericidal peptides holds promise for treating severe blood infections. Peptide insertion in the target membrane and stable binding is desirable, while membrane disruption and release of degradation products to the circulating...

Resource Type:

Dissertation