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Filtering by: Creator Sargent, Roy Geoffrey Date issued sim 1987-03-20

Deoxyribonucleotides as determinants of DNA replication fidelity in bacteriophage T4

Creator:

Sargent, Roy Geoffrey

Abstract:

Imbalanced deoxyribonucleoside triphosphate (dNTP) pools are mutagenic for DNA synthesis in both intact cells and cell-free replication systems. Almost certainly, such mutagenesis involves competition between correctly and incorrectly base-paired precursors at replication sites. However, there are certain differences between the intact cell and cell-free systems that do not always allow...

Resource Type:

Dissertation