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Creator:: Bonventre, Josephine A., Zielke, Ryszard A., Korotkov, Konstantin V., and Sikora, Aleksandra E.
Abstract:: A promising new drug target for the development of novel broad-spectrum antibiotics is the highly conserved small GTPase Obg (YhbZ, CgtA), a protein essential for the survival of all bacteria including Neisseria gonorrhoeae (GC). GC is the agent of gonorrhea, a prevalent sexually transmitted disease resulting in serious consequences on...
Resource Type:: Article
Full Text:: -Spectrum Antibiotics Josephine A. Bonventre1, Ryszard A. Zielke1, Konstantin V. Korotkov2, Aleksandra E

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...
Resource Type:: Article

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...
Full Text:: GTPase and a potential drug target Ryszard A. Zielke, Igor H. Wierzbicki, Benjamin I. Baarda and

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...

Creator:: Park, Bo R., Zielke, Ryszard A., Wierzbicki, Igor H., Mitchell, Kristie C., Withey, Jeffrey H., and Sikora, Aleksandra E.
Abstract:: Vibrio cholerae is autochthonous to various aquatic niches and is the etiological agent of the life-threatening diarrheal disease cholera. The persistence of V. cholerae in natural habitats is a crucial factor in the epidemiology of cholera. In contrast to the well-studied V. cholerae-chitin connection, scarce information is available about the...
Resource Type:: Article

Creator:: Park, Bo R., Zielke, Ryszard A., Wierzbicki, Igor H., Mitchell, Kristie C., Withey, Jeffrey H., and Sikora, Aleksandra E.
Abstract:: Vibrio cholerae is autochthonous to various aquatic niches and is the etiological agent of the life-threatening diarrheal disease cholera. The persistence of V. cholerae in natural habitats is a crucial factor in the epidemiology of cholera. In contrast to the well-studied V. cholerae-chitin connection, scarce information is available about the...
Full Text:: cholerae with Collagen Bo R. Park,a Ryszard A. Zielke,a Igor H. Wierzbicki,a Kristie C. Mitchell,b Jeffrey

Creator:: Zielke, Ryszard A., Simmons, Ryan S., Park, Bo R., Nonogaki, Mariko, Emerson, Sarah, and Sikora, Aleksandra E.
Abstract:: Vibrio cholerae, an etiological agent of cholera, circulates between aquatic reservoirs and the human gastrointestinal tract. The type II secretion (T2S) system plays a pivotal role in both stages of the lifestyle by exporting multiple proteins, including cholera toxin. Here, we studied the kinetics of expression of genes encoding the...
Full Text:: Phase-Dependent Expression of Exoprotein Genes and Is Positively Regulated by �E Ryszard A. Zielke,a

Creator:: Park, Bo R., Zielke, Ryszard A., Wierzbicki, Igor H., Mitchell, Kristie C., Withey, Jeffrey H., and Sikora, Aleksandra E.
Abstract:: Vibrio cholerae is autochthonous to various aquatic niches and is the etiological agent of the life-threatening diarrheal disease cholera. The persistence of V. cholerae in natural habitats is a crucial factor in the epidemiology of cholera. In contrast to the well-studied V. cholerae-chitin connection, scarce information is available about the...
Full Text:: colonization and bacterial transmission experiments as described in a previous study with the following

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