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Filtering by: Creator Tong, Tao Creator Spitsbergen, Jan M.

A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors

Creator:

Li, Zhen, Zheng, Weiling, Wang, Zhengyuan, Zeng, Zhiqiang, Zhan, Huiqing, Li, Caixia, Zhou, Li, Yan, Chuan, Spitsbergen, Jan M., and Gong, Zhiyuan

Abstract:

Myc is a pleiotropic transcription factor that is involved in many cellular activities relevant to carcinogenesis, including hepatocarcinogenesis. The zebrafish has been increasingly used to model human diseases and it is particularly valuable in helping to identify common and conserved molecular mechanisms in vertebrates. Here we generated a liver tumor...

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Article

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. Draheim, K. M., Chen, H. B., Tao, Q., Moore, N., Roche, M. and Lyle, S. (2010). ARRDC3 suppresses breast
A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

Creator:

Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Lam, Siew Hong, Mathavan, Sinnakaruppan, Parinov, Serguei, and Gong, Zhiyuan

Abstract:

Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma (HCC) being the most common type. Aberrant Ras signaling has been implicated in the development and progression of human HCC, but a complete understanding of the molecular mechanisms of this protein in hepatocarcinogenesis remains elusive. In this...

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Article