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The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...
Resource Type:: Article

ZielkeRyszardPharmSciNeisseriaGonorrhoeaeObg.pdf

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...
Full Text:: GTPase and a potential drug target Ryszard A. Zielke, Igor H. Wierzbicki, Benjamin I. Baarda and

ZielkeRyszardPharmSciNeisseriaGonorrhoeaeObgFigureS3.pdf

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...

ZielkeRyszardPharmSciNeisseriaGonorrhoeaeObgFigureS2.pdf

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...

ZielkeRyszardPharmSciNeisseriaGonorrhoeaeObgFigureS1.pdf

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...

A Metalloprotease Secreted by the Type II Secretion System Links Vibrio cholerae with Collagen

Creator:: Park, Bo R., Zielke, Ryszard A., Wierzbicki, Igor H., Mitchell, Kristie C., Withey, Jeffrey H., and Sikora, Aleksandra E.
Abstract:: Vibrio cholerae is autochthonous to various aquatic niches and is the etiological agent of the life-threatening diarrheal disease cholera. The persistence of V. cholerae in natural habitats is a crucial factor in the epidemiology of cholera. In contrast to the well-studied V. cholerae-chitin connection, scarce information is available about the...
Resource Type:: Article

ParkBoPharmacyMetalloproteaseSecretedType.pdf

Creator:: Park, Bo R., Zielke, Ryszard A., Wierzbicki, Igor H., Mitchell, Kristie C., Withey, Jeffrey H., and Sikora, Aleksandra E.
Abstract:: Vibrio cholerae is autochthonous to various aquatic niches and is the etiological agent of the life-threatening diarrheal disease cholera. The persistence of V. cholerae in natural habitats is a crucial factor in the epidemiology of cholera. In contrast to the well-studied V. cholerae-chitin connection, scarce information is available about the...
Full Text:: cholerae with Collagen Bo R. Park,a Ryszard A. Zielke,a Igor H. Wierzbicki,a Kristie C. Mitchell,b Jeffrey

ParkBoPharmacyMetalloproteaseSecretedType_SupplementalMaterial.pdf

Creator:: Park, Bo R., Zielke, Ryszard A., Wierzbicki, Igor H., Mitchell, Kristie C., Withey, Jeffrey H., and Sikora, Aleksandra E.
Abstract:: Vibrio cholerae is autochthonous to various aquatic niches and is the etiological agent of the life-threatening diarrheal disease cholera. The persistence of V. cholerae in natural habitats is a crucial factor in the epidemiology of cholera. In contrast to the well-studied V. cholerae-chitin connection, scarce information is available about the...
Full Text:: colonization and bacterial transmission experiments as described in a previous study with the following

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., Gafken, Philip R., Soge, Olusegun O., Holmes, King K., Jerse, Ann E., Unemo, Magnus, and Sikora, Aleksandra E.
Abstract:: Expanding efforts to develop preventive gonorrhea vaccines is critical because of the dire possibility of untreatable gonococcal infections. Reverse vaccinology, which includes genome and proteome mining, has proven very successful in the discovery of vaccine candidates against many pathogenic bacteria. However, progress with this approach for a gonorrhea vaccine remains...
Resource Type:: Article
Full Text:: Gonorrhea*□S Ryszard A. Zielke‡, Igor H. Wierzbicki‡, Benjamin I. Baarda‡, Philip R. Gafken§, Olusegun O

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Creator:: Wierzbicki, Igor H.
Abstract:: The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Resource Type:: Dissertation
Full Text:: pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the

ScholarsArchive@OSU

The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target

ZielkeRyszardPharmSciNeisseriaGonorrhoeaeObg.pdf

ZielkeRyszardPharmSciNeisseriaGonorrhoeaeObgFigureS3.pdf

ZielkeRyszardPharmSciNeisseriaGonorrhoeaeObgFigureS2.pdf

ZielkeRyszardPharmSciNeisseriaGonorrhoeaeObgFigureS1.pdf

A Metalloprotease Secreted by the Type II Secretion System Links Vibrio cholerae with Collagen

ParkBoPharmacyMetalloproteaseSecretedType.pdf

ParkBoPharmacyMetalloproteaseSecretedType_SupplementalMaterial.pdf

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

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