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Filtering by: Advisor Siemens, Philip J. Creator Woo, Youn Hi Subject Isopentenoids -- Synthesis

Studies of non-mevalonate isoprenoid biosynthesis : the 1-deoxy-D-xylulose-5-phosphate isomeroreductase (DXR) mediated reaction

Creator:

Woo, Youn-Hi

Abstract:

This dissertation details the investigation of an alternate pathway to isoprenoids that occurs in plants and microorganisms, the non-mevalonate pathway. This exploration of the pathway focuses on the second step, the conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methylerythritol-4-phosphate (MEP) by the enzyme DXP isomeroreductase (DXR). These studies led to an appreciation...

Resource Type:

Dissertation

Full Text:

OH [ 0 OH j NADPH OH OH jOPO32 DXP 2-C-methylerythrose -4-phosphate MEP Fig.l.7 The proposed