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Filtering by: Creator Worthington, David H. Date issued sim 1973-09-18

Hydroxyurea : physiological effects on Tetrahymena pyriformis and use in cell cycle analysis

Creator:

Worthington, David H.

Abstract:

Hydroxyurea (10mM) blocks the exponential growth of Tetrahymena pyriformis (GL-I) populations by arresting progress through the cell cycle once the cells enter S-phase. Autoradiographic analysis reveals that HU reduces the uptake of tritiated thymidine (³H-TdR) into macronuclear DNA in S-phase cells to about 1/5 of that in untreated S-phase cells....

Resource Type:

Dissertation