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BaeHaroldPHHSBurdenDiseaseVariants_SupplementalMaterial.pdf

Creator:

Stevenson, Meredith, Bae, Harold, Schupf, Nicole, Andersen, Stacy, Zhang, Qunyuan, Perls, Thomas, and Sebastiani, Paola

Abstract:

Case control studies of nonagenarians and centenarians provide evidence that long‐lived individuals do not differ in the rate of disease associated variants compared to population controls. These results suggest that an enrichment of novel protective variants, rather than a lack of disease associated variants, determine the genetic predisposition to exceptionally...
BaeHaroldPHHSBurdenDiseaseVariants.pdf

Creator:

Stevenson, Meredith, Bae, Harold, Schupf, Nicole, Andersen, Stacy, Zhang, Qunyuan, Perls, Thomas, and Sebastiani, Paola

Abstract:

Case control studies of nonagenarians and centenarians provide evidence that long‐lived individuals do not differ in the rate of disease associated variants compared to population controls. These results suggest that an enrichment of novel protective variants, rather than a lack of disease associated variants, determine the genetic predisposition to exceptionally...
Burden of disease variants in participants of the long life family study

Creator:

Stevenson, Meredith, Bae, Harold, Schupf, Nicole, Andersen, Stacy, Zhang, Qunyuan, Perls, Thomas, and Sebastiani, Paola

Abstract:

Case control studies of nonagenarians and centenarians provide evidence that long‐lived individuals do not differ in the rate of disease associated variants compared to population controls. These results suggest that an enrichment of novel protective variants, rather than a lack of disease associated variants, determine the genetic predisposition to exceptionally...

Resource Type:

Article