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Filtering by: Creator Becker, Kevin G. License Attribution 3.0 United States

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

Creator:

Fok, Wilson C., Bokov, Alex, Gelfond, Jonathan, Yu, Zhen, Zhang, Yiqiang, Doderer, Mark, Chen, Yidong, Javors, Martin, Wood, William H., III, Zhang, Yongqing, Becker, Kevin G., Richardson, Arlan, and Pérez, Viviana I.

Abstract:

Rapamycin (Rapa) and dietary restriction (DR) have consistently been shown to increase lifespan. To investigate whether Rapa and DR affect similar pathways in mice, we compared the effects of feeding mice ad libitum (AL), Rapa, DR, or a combination of Rapa and DR (Rapa + DR) on the transcriptome and...

Resource Type:

Article