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Filtering by: Creator Becker, Kevin G. License CC0 1.0 Universal

Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

Creator:

Fok, Wilson C., Chen, Yidong, Bokov, Alex, Zhang, Yiqiang, Salmon, Adam B., Diaz, Vivian, Javors, Martin, Wood, William H., III, Zhang, Yongqing, Becker, Kevin G., Pérez, Viviana I., and Richardson, Arlan

Abstract:

Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible for rapamycin's longevity effect,...

Resource Type:

Article