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Filtering by: Creator Becker, Kevin G. Resource Type Article

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

Creator:

Fok, Wilson C., Bokov, Alex, Gelfond, Jonathan, Yu, Zhen, Zhang, Yiqiang, Doderer, Mark, Chen, Yidong, Javors, Martin, Wood, William H., III, Zhang, Yongqing, Becker, Kevin G., Richardson, Arlan, and Pérez, Viviana I.

Abstract:

Rapamycin (Rapa) and dietary restriction (DR) have consistently been shown to increase lifespan. To investigate whether Rapa and DR affect similar pathways in mice, we compared the effects of feeding mice ad libitum (AL), Rapa, DR, or a combination of Rapa and DR (Rapa + DR) on the transcriptome and...

Resource Type:

Article
Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

Creator:

Fok, Wilson C., Chen, Yidong, Bokov, Alex, Zhang, Yiqiang, Salmon, Adam B., Diaz, Vivian, Javors, Martin, Wood, William H., III, Zhang, Yongqing, Becker, Kevin G., Pérez, Viviana I., and Richardson, Arlan

Abstract:

Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible for rapamycin's longevity effect,...

Resource Type:

Article