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Creator:: Babrak, Lmar, Danelishvili, Lia, Rose, Sasha J., Kornberg, Tiffany, and Bermudez, Luiz E.
Abstract:: “Mycobacterium avium subsp. hominissuis” is an opportunistic environmental pathogen that causes respiratory illness in immunocompromised patients, such as those with cystic fibrosis as well as other chronic respiratory diseases. Currently, there is no efficient approach to prevent or treat M. avium subsp. hominissuis infection in the lungs. During initial colonization...

Creator:: Babrak, Lmar, Danelishvili, Lia, Rose, Sasha J., Kornberg, Tiffany, and Bermudez, Luiz E.
Abstract:: “Mycobacterium avium subsp. hominissuis” is an opportunistic environmental pathogen that causes respiratory illness in immunocompromised patients, such as those with cystic fibrosis as well as other chronic respiratory diseases. Currently, there is no efficient approach to prevent or treat M. avium subsp. hominissuis infection in the lungs. During initial colonization...

Creator:: Everman, Jamie L., Eckstein, Torsten M., Roussey, Jonathan, Coussens, Paul, Bannantine, John P., and Bermudez, Luiz E.
Abstract:: Understanding the pathogenic mechanisms of Mycobacterium avium subspecies paratuberculosis (MAP) and the host responses to Johne's disease is complicated by the multi-faceted disease progression, late-onset host reaction and the lack of available ex vivo infection models. We describe a novel cell culture passage model that mimics the course of infection...
Resource Type:: Article

Creator:: Babrak, Lmar, Danelishvili, Lia, Rose, Sasha J., Kornberg, Tiffany, and Bermudez, Luiz E.
Abstract:: “Mycobacterium avium subsp. hominissuis” is an opportunistic environmental pathogen that causes respiratory illness in immunocompromised patients, such as those with cystic fibrosis as well as other chronic respiratory diseases. Currently, there is no efficient approach to prevent or treat M. avium subsp. hominissuis infection in the lungs. During initial colonization...
Resource Type:: Article

Creator:: Danelishvili, Lia, Stang, Bernadette, and Bermudez, Luiz E.
Abstract:: M. avium causes disseminated disease in patients with AIDS and other immunosuppressive conditions and pulmonary infections in individuals with chronic lung diseases. Much still need to be learn about the mechanisms of M. avium pathogenesis. Using a mouse model of disseminated M. avium disease, we applied an in vivo expression...
Resource Type:: Article

Creator:: Motamedi, Nima, Danelishvili, Lia, and Bermudez, Luiz E.
Abstract:: Antimicrobial peptides are an important component of the innate immune defense. Mycobacterium avium subsp hominissuis (M. avium) is an organism that establishes contact with the respiratory and gastrointestinal mucosa as a necessary step for infection. M. avium is resistant to high concentrations of polymyxin B, a surrogate for antimicrobial peptides....
Resource Type:: Article

Creator:: Rose, Sasha J. and Bermudez, Luiz E.
Abstract:: Mycobacterium avium subsp. hominissuis is an opportunistic human pathogen that has been shown to form biofilm in vitro and in vivo. Biofilm formation in vivo appears to be associated with infections in the respiratory tract of the host. The reasoning behind how M. avium subsp. hominissuis biofilm is allowed to...
Resource Type:: Article

Creator:: Bannantine, John P. and Bermudez, Luiz E.
Abstract:: The infection biology of Mycobacterium avium subsp. paratuberculosis has recently crystallized, with added details surrounding intestinal invasion. The involvement of pathogen-derived effector proteins such as the major membrane protein, oxidoreductase, and fibronectin attachment proteins have been uncovered. Mutations constructed in this pathogen have also shed light on genes needed for...
Resource Type:: Article

Creator:: Bermudez, Luiz E., Inderlied, Clark B., Kolonoski, Peter, Chee, Christopher B., Aralar, Priscilla, Petrofsky, Mary, Parman, Toufan, Green, Carol E., Lewin, Anita H., Ellis, William Y., and Young, Lowell S.
Abstract:: Infection caused by Mycobacterium avium is common in AIDS patients who do not receive treatment with highly active antiretroviral therapy (HAART) or who develop resistance to anti-HIV therapy. Mefloquine, a racemic mixture used for malaria prophylaxis and treatment, is bactericidal against M. avium in mice. MICs of (+)-erythro-, (−)-erythro-, (+)-threo-,...
Resource Type:: Article

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