Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Subject Microsomes -- Effect of chemicals on Creator Buckholz, Cheryl J.

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Creator:

Buckholz, Cheryl J.

Abstract:

Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...

Resource Type:

Dissertation

Full Text:

either phase I or phase II enzymes could have an effect on the efficacy or toxicity of therapeutic drugs