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Filtering by: Creator Coleman, Daniel J. Subject Skin -- Cancer -- Genetic aspects

Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

Creator:

Coleman, Daniel J.

Abstract:

Melanoma is the deadliest form of skin cancer, arising from malignant transformation of pigment-producing melanocytes. The primary risk factor for melanoma and other skin cancers is DNA damage resulting from unprotected solar ultraviolet radiation (UVR). If incorrectly repaired, this damage can result in incorporation of mutations that cause aberrant cell...

Resource Type:

Dissertation