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Creator:: Bermudez, Luiz E., Danelishvili, Lia, Babrack, Lmar, and Pham, Tuan
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) is an environmental bacteria that infects immunocompromised humans. MAH cases are increasing in incidence, making it crucial to gain knowledge of the pathogenic mechanisms associated with the bacterium. MAH infects macrophages and after several days the infection triggers the phagocyte apoptosis. Many of the intracellular...
Resource Type:: Article

Creator:: Babrak, Lmar, Danelishvili, Lia, Rose, Sasha J., Kornberg, Tiffany, and Bermudez, Luiz E.
Abstract:: “Mycobacterium avium subsp. hominissuis” is an opportunistic environmental pathogen that causes respiratory illness in immunocompromised patients, such as those with cystic fibrosis as well as other chronic respiratory diseases. Currently, there is no efficient approach to prevent or treat M. avium subsp. hominissuis infection in the lungs. During initial colonization...
Resource Type:: Article

Creator:: Danelishvili, Lia, Stang, Bernadette, and Bermudez, Luiz E.
Abstract:: M. avium causes disseminated disease in patients with AIDS and other immunosuppressive conditions and pulmonary infections in individuals with chronic lung diseases. Much still need to be learn about the mechanisms of M. avium pathogenesis. Using a mouse model of disseminated M. avium disease, we applied an in vivo expression...
Resource Type:: Article

Creator:: Motamedi, Nima, Danelishvili, Lia, and Bermudez, Luiz E.
Abstract:: Antimicrobial peptides are an important component of the innate immune defense. Mycobacterium avium subsp hominissuis (M. avium) is an organism that establishes contact with the respiratory and gastrointestinal mucosa as a necessary step for infection. M. avium is resistant to high concentrations of polymyxin B, a surrogate for antimicrobial peptides....
Resource Type:: Article

Creator:: Danelishvili, Lia, Babrak, Lmar, Rose, Sasha J., Everman, Jamie, and Bermudez, Luiz E.
Abstract:: Inhibition of apoptotic death of macrophages by Mycobacterium tuberculosis represents an important mechanism of virulence that results in pathogen survival both in vitro and in vivo. To identify M. tuberculosis virulence determinants involved in the modulation of apoptosis, we previously screened a transposon bank of mutants in human macrophages, and...
Resource Type:: Article

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