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Filtering by: Creator Dowell, Paul T. Remove constraint Creator: Dowell, Paul T. Resource Type Dissertation Remove constraint Resource Type: Dissertation

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  • Molecular mechanisms of peroxisome proliferator-activated receptor signaling

    Creator:
    Dowell, Paul T.
    Abstract:
    Peroxisome proliferator-activated receptors (PPARs) are members of a large group of ligand-regulated transcription factors that includes nuclear receptors for steroid and thyroid hormones, retinoids and vitamin D₃. Synthetic fibrates and thiazolidinediones that bind to and activate PPARs are used efficaciously in humans to remedy hypertriglyceridemia and non-insulin dependent diabetes mellitus,...
    Resource Type:
    Dissertation