An asymmetric approach to the synthesis of byssochlamic acid (1) is
described. Regioisomeric enzymatic differentiation is described in the selective
hydrolysis of dimethyl ester 30 by porcine liver esterase. Chiral dimethyl ester 42
was prepared by desymmetrization of cyclopentene 34 using porcine liver
esterase. A key intramolecular [2+2]cycloaddition-cycloreversion
photometathesis of...